Regulatory functions of human CD4 + T cells recognizing allopeptides in the context of self-HLA class II

Pretransplant blood transfusions sharing one human leukocyte antigen DR (HLA-DR) with the recipient have been shown to enhance graft survival, whereas HLA-DR mismatched blood transfusions will lead to immunization of the patient. The involvement of self HLA-DR suggests a role for CD4 + regulatory T...

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