Polymorphism analysis of the upstream region of the human N-methyl- d-aspartate receptor subunit NR1 gene ( GRIN1): implications for schizophrenia

Dysfunction of the gene for the NR1 subunit of the N-methyl- d-aspartate (NMDA) receptor ( GRIN1) has been implicated in the pathogenesis of schizophrenia. In support of this hypothesis are behavioral abnormalities reminiscent of schizophrenia in mice with an attenuated expression of the NR1 subunit...

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Veröffentlicht in:	Schizophrenia research 2002-11, Vol.58 (1), p.83-86
Hauptverfasser:	Tani, Ayako, Kikuta, Rumiko, Itoh, Kanako, Joo, Akiko, Shibata, Hiroki, Ninomiya, Hideaki, Tashiro, Nobutada, Fukumaki, Yasuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Adult and adolescent clinical studies Alleles Association Biological and medical sciences Chi-Square Distribution Female Genotype Humans Male Medical sciences Middle Aged N-methyl- d-aspartate receptor subunit NR1 gene ( GRIN1) Polymerase Chain Reaction Polymorphism Polymorphism, Single Nucleotide Polymorphism, Single-Stranded Conformational Promoter Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptors, N-Methyl-D-Aspartate - genetics Schizophrenia Schizophrenia - genetics Sequence Analysis, DNA Transcription
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