Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling

Summary The most important group of antifungals is the azoles (e.g. miconazole), which act by inhibiting lanosterol demethylase in the sterol biosynthesis pathway. Azole activity can be modulated through structural changes in lanosterol demethylase, altered expression of its gene ERG11, alterations...

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Veröffentlicht in:	Molecular microbiology 2002-10, Vol.46 (1), p.257-268
Hauptverfasser:	Edlind, Thomas, Smith, Lamar, Henry, Karl, Katiyar, Santosh, Nickels, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Azoles - pharmacology Calcineurin Inhibitors Calcium - metabolism Calcium Signaling Calmodulin - antagonists & inhibitors Egtazic Acid - pharmacology Gene Expression Regulation, Fungal Humans Models, Biological Naphthalenes - pharmacology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Tacrolimus - pharmacology Terbinafine
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