Homologous pancreastatin inhibits insulin secretion without affecting glucagon and somatostatin release in the perfused rat pancreas

The identification of pancreastatin in pancreatic extracts prompted the investigation of its effects on islet cell function. However, in most of the investigations to date, pig pancreastatin was tested in heterologous species. Since there is great interspecies variability in the amino acid sequence...

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Veröffentlicht in:	Regulatory peptides 1991-07, Vol.34 (3), p.159-167
Hauptverfasser:	Peiró, Elena, Dégano, Pilar, Miralles, Paloma, Silvestre, Ramona A., Marco, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - physiology Biological and medical sciences Chromogranin A Endocrine pancreas Fundamental and applied biological sciences. Psychology Glucagon Glucagon - metabolism Glucose - physiology Hormones. Régulation Insulin Insulin - metabolism Insulin Antagonists - pharmacology Insulin Secretion Male Pancreas - drug effects Pancreas - metabolism Pancreatic Hormones - pharmacology Perfusion Rat pancreas Rat pancreastatin Rats Rats, Inbred Strains Somatostatin Somatostatin - metabolism Vasoactive Intestinal Peptide - physiology Vertebrates: endocrinology
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