Identifying patients with symptomatic carotid artery disease at high and low risk of severe myocardial infarction and cardiac death
The extent of cardiac investigation required in patients with coexistent symptomatic carotid and cardiac disease is unsettled. This study compared the outlook for patients symptomatic from carotid stenosis with and without a history of symptomatic ischemic heart disease (IHD). The risk of combined o...
Gespeichert in:
| Veröffentlicht in: | Stroke (1970) 2002-10, Vol.33 (10), p.2413-2416 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2416 |
|---|---|
| container_issue | 10 |
| container_start_page | 2413 |
| container_title | Stroke (1970) |
| container_volume | 33 |
| creator | GATES, Peter C ELIASZIW, Michael ALGRA, Ale BARNETT, Henry J. M GUNTON, Ramsay W |
| description | The extent of cardiac investigation required in patients with coexistent symptomatic carotid and cardiac disease is unsettled. This study compared the outlook for patients symptomatic from carotid stenosis with and without a history of symptomatic ischemic heart disease (IHD).
The risk of combined outcome of severe myocardial infarction and cardiac death was evaluated in patients from the North American Symptomatic Carotid Endarterectomy Trial.
A total of 1124 patients had a history of symptomatic IHD and 1691 did not. The median age was 66 years; 70% were male. With history of IHD at entry, the 5-year risk of combined outcome of severe myocardial infarction and cardiac death was 16.5% (95% CI, 13.9 to 19.0). Without history at entry, risk was 6.7% (95% CI, 5.1 to 8.3). Risk of unheralded severe MI and cardiac death was only 3.3%. One hundred ninety-four patients had > or =4 of the following risk factors: age > or =75 years, history of diabetes, history of hypertension, smoking in past year, left ventricular hypertrophy on ECG, myocardial infarction on ECG, or creatinine >115 micromol/L. The 5-year risk of severe myocardial infarction or cardiac death increased to 33.9% for patients with > or =4 risk factors and a history of IHD and to 23.5% for those without history of IHD.
Most patients with symptomatic carotid stenosis without symptomatic IHD had a low risk of severe myocardial infarction and cardiac death. With many risk factors, these patients had a risk high enough to warrant cardiac investigations. |
| doi_str_mv | 10.1161/01.STR.0000030110.05246.2C |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72153420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>212607271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-71a5c2f5d911d5aad1a8f6b15803751c9ac65059036a1324026cb97db42fdb0d3</originalsourceid><addsrcrecordid>eNpdkU9rFDEchoModlv9ChIKeps1fycTb7JoLRQErefwmyTTTZ2ZrEm2Zc5-cdPuwoK5JHnzvEngQeiSkjWlLf1I6Prn7Y81eRqc0BoTyUS7ZpsXaEXrshEt616iVT3WDRNan6HznO8rzngnX6MzyngrFCcr9Pfa-bmEYQnzHd5BCXWX8WMoW5yXaVfiVDOLLaRYgsOQik8LdiF7yB5Dwdtwt8UwOzzGR5xC_o3jgLN_8MnjaYm16AKMOMwDJFtCnJ_hQ2yx81C2b9CrAcbs3x7nC_Tr65fbzbfm5vvV9ebzTWNFS0ujKEjLBuk0pU4COArd0PZUdoQrSa0G20oiNeEtUM4EYa3ttXK9YIPrieMX6MPh3l2Kf_Y-FzOFbP04wuzjPhvFqOSCkQpe_gfex32a698M1UopqTpRoU8HyKaYc_KD2aUwQVoMJebJkyHUVE_m5Mk8ezJsU8vvji_s-8m7U_UopgLvjwBkC-OQYLYhnziuleBK83-AHZ0y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197775784</pqid></control><display><type>article</type><title>Identifying patients with symptomatic carotid artery disease at high and low risk of severe myocardial infarction and cardiac death</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><creator>GATES, Peter C ; ELIASZIW, Michael ; ALGRA, Ale ; BARNETT, Henry J. M ; GUNTON, Ramsay W</creator><creatorcontrib>GATES, Peter C ; ELIASZIW, Michael ; ALGRA, Ale ; BARNETT, Henry J. M ; GUNTON, Ramsay W ; North American Symptomatic Carotid Endarterectomy Trial Group</creatorcontrib><description>The extent of cardiac investigation required in patients with coexistent symptomatic carotid and cardiac disease is unsettled. This study compared the outlook for patients symptomatic from carotid stenosis with and without a history of symptomatic ischemic heart disease (IHD).
The risk of combined outcome of severe myocardial infarction and cardiac death was evaluated in patients from the North American Symptomatic Carotid Endarterectomy Trial.
A total of 1124 patients had a history of symptomatic IHD and 1691 did not. The median age was 66 years; 70% were male. With history of IHD at entry, the 5-year risk of combined outcome of severe myocardial infarction and cardiac death was 16.5% (95% CI, 13.9 to 19.0). Without history at entry, risk was 6.7% (95% CI, 5.1 to 8.3). Risk of unheralded severe MI and cardiac death was only 3.3%. One hundred ninety-four patients had > or =4 of the following risk factors: age > or =75 years, history of diabetes, history of hypertension, smoking in past year, left ventricular hypertrophy on ECG, myocardial infarction on ECG, or creatinine >115 micromol/L. The 5-year risk of severe myocardial infarction or cardiac death increased to 33.9% for patients with > or =4 risk factors and a history of IHD and to 23.5% for those without history of IHD.
Most patients with symptomatic carotid stenosis without symptomatic IHD had a low risk of severe myocardial infarction and cardiac death. With many risk factors, these patients had a risk high enough to warrant cardiac investigations.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000030110.05246.2C</identifier><identifier>PMID: 12364730</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Cardiology. Vascular system ; Carotid Artery Diseases - epidemiology ; Carotid Artery Diseases - surgery ; Comorbidity ; Controlled Clinical Trials as Topic - statistics & numerical data ; Coronary heart disease ; Death, Sudden, Cardiac - epidemiology ; Disease-Free Survival ; Electrocardiography ; Endarterectomy, Carotid ; Female ; Follow-Up Studies ; Heart ; Humans ; Male ; Medical sciences ; Myocardial Infarction - epidemiology ; Myocardial Infarction - surgery ; Myocardial Ischemia - epidemiology ; Odds Ratio ; Risk Assessment ; Risk Factors ; Treatment Outcome</subject><ispartof>Stroke (1970), 2002-10, Vol.33 (10), p.2413-2416</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Oct 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-71a5c2f5d911d5aad1a8f6b15803751c9ac65059036a1324026cb97db42fdb0d3</citedby><cites>FETCH-LOGICAL-c461t-71a5c2f5d911d5aad1a8f6b15803751c9ac65059036a1324026cb97db42fdb0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13974379$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12364730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GATES, Peter C</creatorcontrib><creatorcontrib>ELIASZIW, Michael</creatorcontrib><creatorcontrib>ALGRA, Ale</creatorcontrib><creatorcontrib>BARNETT, Henry J. M</creatorcontrib><creatorcontrib>GUNTON, Ramsay W</creatorcontrib><creatorcontrib>North American Symptomatic Carotid Endarterectomy Trial Group</creatorcontrib><title>Identifying patients with symptomatic carotid artery disease at high and low risk of severe myocardial infarction and cardiac death</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>The extent of cardiac investigation required in patients with coexistent symptomatic carotid and cardiac disease is unsettled. This study compared the outlook for patients symptomatic from carotid stenosis with and without a history of symptomatic ischemic heart disease (IHD).
The risk of combined outcome of severe myocardial infarction and cardiac death was evaluated in patients from the North American Symptomatic Carotid Endarterectomy Trial.
A total of 1124 patients had a history of symptomatic IHD and 1691 did not. The median age was 66 years; 70% were male. With history of IHD at entry, the 5-year risk of combined outcome of severe myocardial infarction and cardiac death was 16.5% (95% CI, 13.9 to 19.0). Without history at entry, risk was 6.7% (95% CI, 5.1 to 8.3). Risk of unheralded severe MI and cardiac death was only 3.3%. One hundred ninety-four patients had > or =4 of the following risk factors: age > or =75 years, history of diabetes, history of hypertension, smoking in past year, left ventricular hypertrophy on ECG, myocardial infarction on ECG, or creatinine >115 micromol/L. The 5-year risk of severe myocardial infarction or cardiac death increased to 33.9% for patients with > or =4 risk factors and a history of IHD and to 23.5% for those without history of IHD.
Most patients with symptomatic carotid stenosis without symptomatic IHD had a low risk of severe myocardial infarction and cardiac death. With many risk factors, these patients had a risk high enough to warrant cardiac investigations.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery Diseases - surgery</subject><subject>Comorbidity</subject><subject>Controlled Clinical Trials as Topic - statistics & numerical data</subject><subject>Coronary heart disease</subject><subject>Death, Sudden, Cardiac - epidemiology</subject><subject>Disease-Free Survival</subject><subject>Electrocardiography</subject><subject>Endarterectomy, Carotid</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - surgery</subject><subject>Myocardial Ischemia - epidemiology</subject><subject>Odds Ratio</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9rFDEchoModlv9ChIKeps1fycTb7JoLRQErefwmyTTTZ2ZrEm2Zc5-cdPuwoK5JHnzvEngQeiSkjWlLf1I6Prn7Y81eRqc0BoTyUS7ZpsXaEXrshEt616iVT3WDRNan6HznO8rzngnX6MzyngrFCcr9Pfa-bmEYQnzHd5BCXWX8WMoW5yXaVfiVDOLLaRYgsOQik8LdiF7yB5Dwdtwt8UwOzzGR5xC_o3jgLN_8MnjaYm16AKMOMwDJFtCnJ_hQ2yx81C2b9CrAcbs3x7nC_Tr65fbzbfm5vvV9ebzTWNFS0ujKEjLBuk0pU4COArd0PZUdoQrSa0G20oiNeEtUM4EYa3ttXK9YIPrieMX6MPh3l2Kf_Y-FzOFbP04wuzjPhvFqOSCkQpe_gfex32a698M1UopqTpRoU8HyKaYc_KD2aUwQVoMJebJkyHUVE_m5Mk8ezJsU8vvji_s-8m7U_UopgLvjwBkC-OQYLYhnziuleBK83-AHZ0y</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>GATES, Peter C</creator><creator>ELIASZIW, Michael</creator><creator>ALGRA, Ale</creator><creator>BARNETT, Henry J. M</creator><creator>GUNTON, Ramsay W</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Identifying patients with symptomatic carotid artery disease at high and low risk of severe myocardial infarction and cardiac death</title><author>GATES, Peter C ; ELIASZIW, Michael ; ALGRA, Ale ; BARNETT, Henry J. M ; GUNTON, Ramsay W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-71a5c2f5d911d5aad1a8f6b15803751c9ac65059036a1324026cb97db42fdb0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Artery Diseases - surgery</topic><topic>Comorbidity</topic><topic>Controlled Clinical Trials as Topic - statistics & numerical data</topic><topic>Coronary heart disease</topic><topic>Death, Sudden, Cardiac - epidemiology</topic><topic>Disease-Free Survival</topic><topic>Electrocardiography</topic><topic>Endarterectomy, Carotid</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - surgery</topic><topic>Myocardial Ischemia - epidemiology</topic><topic>Odds Ratio</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GATES, Peter C</creatorcontrib><creatorcontrib>ELIASZIW, Michael</creatorcontrib><creatorcontrib>ALGRA, Ale</creatorcontrib><creatorcontrib>BARNETT, Henry J. M</creatorcontrib><creatorcontrib>GUNTON, Ramsay W</creatorcontrib><creatorcontrib>North American Symptomatic Carotid Endarterectomy Trial Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GATES, Peter C</au><au>ELIASZIW, Michael</au><au>ALGRA, Ale</au><au>BARNETT, Henry J. M</au><au>GUNTON, Ramsay W</au><aucorp>North American Symptomatic Carotid Endarterectomy Trial Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identifying patients with symptomatic carotid artery disease at high and low risk of severe myocardial infarction and cardiac death</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>33</volume><issue>10</issue><spage>2413</spage><epage>2416</epage><pages>2413-2416</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>The extent of cardiac investigation required in patients with coexistent symptomatic carotid and cardiac disease is unsettled. This study compared the outlook for patients symptomatic from carotid stenosis with and without a history of symptomatic ischemic heart disease (IHD).
The risk of combined outcome of severe myocardial infarction and cardiac death was evaluated in patients from the North American Symptomatic Carotid Endarterectomy Trial.
A total of 1124 patients had a history of symptomatic IHD and 1691 did not. The median age was 66 years; 70% were male. With history of IHD at entry, the 5-year risk of combined outcome of severe myocardial infarction and cardiac death was 16.5% (95% CI, 13.9 to 19.0). Without history at entry, risk was 6.7% (95% CI, 5.1 to 8.3). Risk of unheralded severe MI and cardiac death was only 3.3%. One hundred ninety-four patients had > or =4 of the following risk factors: age > or =75 years, history of diabetes, history of hypertension, smoking in past year, left ventricular hypertrophy on ECG, myocardial infarction on ECG, or creatinine >115 micromol/L. The 5-year risk of severe myocardial infarction or cardiac death increased to 33.9% for patients with > or =4 risk factors and a history of IHD and to 23.5% for those without history of IHD.
Most patients with symptomatic carotid stenosis without symptomatic IHD had a low risk of severe myocardial infarction and cardiac death. With many risk factors, these patients had a risk high enough to warrant cardiac investigations.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12364730</pmid><doi>10.1161/01.STR.0000030110.05246.2C</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 2002-10, Vol.33 (10), p.2413-2416 |
| issn | 0039-2499 1524-4628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72153420 |
| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Biological and medical sciences Cardiology. Vascular system Carotid Artery Diseases - epidemiology Carotid Artery Diseases - surgery Comorbidity Controlled Clinical Trials as Topic - statistics & numerical data Coronary heart disease Death, Sudden, Cardiac - epidemiology Disease-Free Survival Electrocardiography Endarterectomy, Carotid Female Follow-Up Studies Heart Humans Male Medical sciences Myocardial Infarction - epidemiology Myocardial Infarction - surgery Myocardial Ischemia - epidemiology Odds Ratio Risk Assessment Risk Factors Treatment Outcome |
| title | Identifying patients with symptomatic carotid artery disease at high and low risk of severe myocardial infarction and cardiac death |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T09%3A41%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identifying%20patients%20with%20symptomatic%20carotid%20artery%20disease%20at%20high%20and%20low%20risk%20of%20severe%20myocardial%20infarction%20and%20cardiac%20death&rft.jtitle=Stroke%20(1970)&rft.au=GATES,%20Peter%20C&rft.aucorp=North%20American%20Symptomatic%20Carotid%20Endarterectomy%20Trial%20Group&rft.date=2002-10-01&rft.volume=33&rft.issue=10&rft.spage=2413&rft.epage=2416&rft.pages=2413-2416&rft.issn=0039-2499&rft.eissn=1524-4628&rft.coden=SJCCA7&rft_id=info:doi/10.1161/01.STR.0000030110.05246.2C&rft_dat=%3Cproquest_cross%3E212607271%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=197775784&rft_id=info:pmid/12364730&rfr_iscdi=true |