Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC with UV detection

A simple and accurate high-performance liquid chromatographic method with ultraviolet detection at 220 nm has been validated for the simultaneous determination of amoxicillin and clavulanic acid in human plasma. Plasma samples were pretreated by direct deproteinization with methanol. A good chromato...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2002-10, Vol.30 (3), p.661-666
Hauptverfasser:	Hoizey, Guillaume, Lamiable, Denis, Frances, Carole, Trenque, Thierry, Kaltenbach, Matthieu, Denis, Jacky, Millart, Hervé
Format:	Artikel
Sprache:	eng
Schlagworte:	Amoxicillin Amoxicillin - blood Amoxicillin-Potassium Clavulanate Combination - blood Analysis Biological and medical sciences Biological samples Chromatography, High Pressure Liquid - methods Clavulanic acid Clavulanic Acid - blood General pharmacology Humans Male Medical sciences Pharmacology. Drug treatments Reversed phase HPLC-UV assay Spectrophotometry, Ultraviolet - methods
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