Choline inhibition of prothrombin activation

A computer-interfaced spectrophotometric kinetic assay for prothrombin activation was developed, coupling the production of thrombin to a thrombin-specific amidolytic chromogenic reaction. As thrombin accumulated initially at constant velocity, the simultaneous release from S-2238 of pNA conformed t...

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Veröffentlicht in:	Thrombosis research 1991-06, Vol.62 (6), p.635-648
Hauptverfasser:	Leach, Richard D., Dewind, Sally A., Slattery, Charles W., Herrmann, E.Clifford
Format:	Artikel
Sprache:	eng
Schlagworte:	anticoagulant Aspirin - pharmacology Biological and medical sciences Blood coagulation. Blood cells Calcium - pharmacology choline Choline - pharmacology chromogenic peptide substrate Coagulation factors Dipeptides - pharmacology Enzyme Activation - drug effects enzyme inhibitor factor Va Factor Xa Inhibitors Fundamental and applied biological sciences. Psychology Humans Kinetics Liposomes Microcomputers Molecular and cellular biology Phospholipids - pharmacology Prothrombin - metabolism prothrombinase Spectrophotometry Thromboplastin - antagonists & inhibitors
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