A new predictive equation for the solubility of drugs based on the thermodynamics of mobile disorder

The thermodynamics of mobile disorder rejects the static model of the quasi-lattice for liquids. Because cause of the perpetual change of neighbors, during the observation time of thermodynamics of the order of seconds, each molecule of a given kind in a solution has experienced the same environment...

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Veröffentlicht in:	Pharmaceutical research 1991-07, Vol.8 (7), p.840-850
Hauptverfasser:	RUELLE, P, REY-MERMET, C, BUCHMANN, M, HO NAM-TRAN, KESSELRING, U. W, HUYSKENS, P. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical Phenomena Chemistry, Pharmaceutical Chemistry, Physical General pharmacology Hydrogen Bonding Medical sciences Parabens - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Protons Solubility Solvents Thermodynamics
Online-Zugang:	Volltext
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