Effect of Alstonia Scholaris bark extract on testicular function of Wistar rats
Aim:To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats.Methods:In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200mg/day for60days,The fertility and testicular function were assessed by mating tests,sperm motility,sperm conce...
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| Veröffentlicht in: | Asian journal of andrology 2002-09, Vol.4 (3), p.175-178 |
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| creator | GUPTA, R. S SHARMA, Rakhi SHARMA, Aruna BHATNAGER, A. K DOBHAL, M. P JOSHI, Y. C SHARMA, M. C |
| description | Aim:To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats.Methods:In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200mg/day for60days,The fertility and testicular function were assessed by mating tests,sperm motility,sperm concentration,biochemical indices and testicular cell population dynamics.Results:Oral feeding with the extract at a dose of 200mg/day for the period of 60days did not cause body weight loss,while the weights of testes,epididymides,seminal vesicle and ventral prostate were significantly reduced.The production of step-19 spermatids was reduced by 79.6%in treated rats.The popu-lation of preleptotene and pachytene spermatocytes were decrased by61.9%and60.1%,respectively.Spematogo-nia and Sertoli cell population were also affected.The seminiferous tubule and Leydig cell nuclear area were reduced significantly(P |
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S ; SHARMA, Rakhi ; SHARMA, Aruna ; BHATNAGER, A. K ; DOBHAL, M. P ; JOSHI, Y. C ; SHARMA, M. C</creator><creatorcontrib>GUPTA, R. S ; SHARMA, Rakhi ; SHARMA, Aruna ; BHATNAGER, A. K ; DOBHAL, M. P ; JOSHI, Y. C ; SHARMA, M. C</creatorcontrib><description>Aim:To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats.Methods:In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200mg/day for60days,The fertility and testicular function were assessed by mating tests,sperm motility,sperm concentration,biochemical indices and testicular cell population dynamics.Results:Oral feeding with the extract at a dose of 200mg/day for the period of 60days did not cause body weight loss,while the weights of testes,epididymides,seminal vesicle and ventral prostate were significantly reduced.The production of step-19 spermatids was reduced by 79.6%in treated rats.The popu-lation of preleptotene and pachytene spermatocytes were decrased by61.9%and60.1%,respectively.Spematogo-nia and Sertoli cell population were also affected.The seminiferous tubule and Leydig cell nuclear area were reduced significantly(P<0.01)when compared to the controls..Reduced sperm count and motility yesulted in a total supprs-sion of fertility.A significant fall in the protein and sialic acid content of the testes,epididymides,seminal vesicle and ventral prostate as well as glycogen content of testes were also noticed.The fructose content in the seminal vesicle was lowered whereas the testicular cholesterol was elevated as compared with the controls.The following com-pounds were obtained from the extract with chromatographic separation over Si-gel column;α-amyrin,β-amyrin,lupiol acetate,venenative,rhazine and yohimbine,Conclusion:At the dose level employed,Alstonia scholaris bark extract has a significant antifertility effect in male rast;the primary site of action may be post meiotic germ cells(Step19spermatids).</description><identifier>ISSN: 1008-682X</identifier><identifier>EISSN: 1745-7262</identifier><identifier>PMID: 12364971</identifier><language>eng</language><publisher>Oxford: blackwell</publisher><subject>Administration, Oral ; Alstonia ; Animals ; Biological and medical sciences ; Body Weight ; Drug toxicity and drugs side effects treatment ; Infertility, Male - drug therapy ; Male ; Medical sciences ; Organ Size ; Pharmacology. Drug treatments ; Plant Bark ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Spermatozoa - drug effects ; Testis - drug effects ; Toxicity: urogenital system ; Tropical medicine ; 作用机理 ; 夹竹桃 ; 提取物 ; 精子活性</subject><ispartof>Asian journal of andrology, 2002-09, Vol.4 (3), p.175-178</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84127X/84127X.jpg</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13927227$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12364971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GUPTA, R. S</creatorcontrib><creatorcontrib>SHARMA, Rakhi</creatorcontrib><creatorcontrib>SHARMA, Aruna</creatorcontrib><creatorcontrib>BHATNAGER, A. K</creatorcontrib><creatorcontrib>DOBHAL, M. P</creatorcontrib><creatorcontrib>JOSHI, Y. C</creatorcontrib><creatorcontrib>SHARMA, M. C</creatorcontrib><title>Effect of Alstonia Scholaris bark extract on testicular function of Wistar rats</title><title>Asian journal of andrology</title><addtitle>Asian Journal of Andrology</addtitle><description>Aim:To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats.Methods:In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200mg/day for60days,The fertility and testicular function were assessed by mating tests,sperm motility,sperm concentration,biochemical indices and testicular cell population dynamics.Results:Oral feeding with the extract at a dose of 200mg/day for the period of 60days did not cause body weight loss,while the weights of testes,epididymides,seminal vesicle and ventral prostate were significantly reduced.The production of step-19 spermatids was reduced by 79.6%in treated rats.The popu-lation of preleptotene and pachytene spermatocytes were decrased by61.9%and60.1%,respectively.Spematogo-nia and Sertoli cell population were also affected.The seminiferous tubule and Leydig cell nuclear area were reduced significantly(P<0.01)when compared to the controls..Reduced sperm count and motility yesulted in a total supprs-sion of fertility.A significant fall in the protein and sialic acid content of the testes,epididymides,seminal vesicle and ventral prostate as well as glycogen content of testes were also noticed.The fructose content in the seminal vesicle was lowered whereas the testicular cholesterol was elevated as compared with the controls.The following com-pounds were obtained from the extract with chromatographic separation over Si-gel column;α-amyrin,β-amyrin,lupiol acetate,venenative,rhazine and yohimbine,Conclusion:At the dose level employed,Alstonia scholaris bark extract has a significant antifertility effect in male rast;the primary site of action may be post meiotic germ cells(Step19spermatids).</description><subject>Administration, Oral</subject><subject>Alstonia</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Infertility, Male - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Size</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Bark</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spermatozoa - drug effects</subject><subject>Testis - drug effects</subject><subject>Toxicity: urogenital system</subject><subject>Tropical medicine</subject><subject>作用机理</subject><subject>夹竹桃</subject><subject>提取物</subject><subject>精子活性</subject><issn>1008-682X</issn><issn>1745-7262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0F9LwzAQAPAiipvTryD1Qd8KzaVpkscx5h8Y7EFF38olS2Zc125JCvrtjWziU46734W7O8nGhFes4FDDaYrLUhS1gPdRdhHCZ1kCJVKeZyMCtK4kJ-NsObfW6Jj3Np-2Ifadw_xZf_QtehdyhX6Tm6_o8Zd0eTQhOj2kYm6HTkeXcqnzzYWYUh5juMzOLLbBXB3fSfZ6P3-ZPRaL5cPTbLooNJEsFrCiCpWsNWWCC1VXYBjXK8OBEWIIEVQrxoQABRVfSVHXoCwir0pg3BJCJ9nd4d-d7_dDGqvZuqBN22Jn-iE0HAhLW0KC10c4qK1ZNTvvtui_m78TJHB7BBg0ttZjp134d1QCB-DJ3Rxcuk633rtu3SjUG-ta0_CSVFRI-gMz7nAQ</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>GUPTA, R. S</creator><creator>SHARMA, Rakhi</creator><creator>SHARMA, Aruna</creator><creator>BHATNAGER, A. K</creator><creator>DOBHAL, M. P</creator><creator>JOSHI, Y. C</creator><creator>SHARMA, M. C</creator><general>blackwell</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Effect of Alstonia Scholaris bark extract on testicular function of Wistar rats</title><author>GUPTA, R. S ; SHARMA, Rakhi ; SHARMA, Aruna ; BHATNAGER, A. K ; DOBHAL, M. P ; JOSHI, Y. C ; SHARMA, M. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c195t-2d3bab96c35878b642e57cde72511e1183cb55882b247d98662bfaa740257f113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Oral</topic><topic>Alstonia</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Infertility, Male - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Size</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Bark</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spermatozoa - drug effects</topic><topic>Testis - drug effects</topic><topic>Toxicity: urogenital system</topic><topic>Tropical medicine</topic><topic>作用机理</topic><topic>夹竹桃</topic><topic>提取物</topic><topic>精子活性</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GUPTA, R. S</creatorcontrib><creatorcontrib>SHARMA, Rakhi</creatorcontrib><creatorcontrib>SHARMA, Aruna</creatorcontrib><creatorcontrib>BHATNAGER, A. K</creatorcontrib><creatorcontrib>DOBHAL, M. P</creatorcontrib><creatorcontrib>JOSHI, Y. C</creatorcontrib><creatorcontrib>SHARMA, M. C</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Asian journal of andrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GUPTA, R. S</au><au>SHARMA, Rakhi</au><au>SHARMA, Aruna</au><au>BHATNAGER, A. K</au><au>DOBHAL, M. P</au><au>JOSHI, Y. C</au><au>SHARMA, M. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Alstonia Scholaris bark extract on testicular function of Wistar rats</atitle><jtitle>Asian journal of andrology</jtitle><addtitle>Asian Journal of Andrology</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>4</volume><issue>3</issue><spage>175</spage><epage>178</epage><pages>175-178</pages><issn>1008-682X</issn><eissn>1745-7262</eissn><abstract>Aim:To evaluate the antifertility effect of Alstonia scholaris bark extract in male rats.Methods:In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200mg/day for60days,The fertility and testicular function were assessed by mating tests,sperm motility,sperm concentration,biochemical indices and testicular cell population dynamics.Results:Oral feeding with the extract at a dose of 200mg/day for the period of 60days did not cause body weight loss,while the weights of testes,epididymides,seminal vesicle and ventral prostate were significantly reduced.The production of step-19 spermatids was reduced by 79.6%in treated rats.The popu-lation of preleptotene and pachytene spermatocytes were decrased by61.9%and60.1%,respectively.Spematogo-nia and Sertoli cell population were also affected.The seminiferous tubule and Leydig cell nuclear area were reduced significantly(P<0.01)when compared to the controls..Reduced sperm count and motility yesulted in a total supprs-sion of fertility.A significant fall in the protein and sialic acid content of the testes,epididymides,seminal vesicle and ventral prostate as well as glycogen content of testes were also noticed.The fructose content in the seminal vesicle was lowered whereas the testicular cholesterol was elevated as compared with the controls.The following com-pounds were obtained from the extract with chromatographic separation over Si-gel column;α-amyrin,β-amyrin,lupiol acetate,venenative,rhazine and yohimbine,Conclusion:At the dose level employed,Alstonia scholaris bark extract has a significant antifertility effect in male rast;the primary site of action may be post meiotic germ cells(Step19spermatids).</abstract><cop>Oxford</cop><pub>blackwell</pub><pmid>12364971</pmid><tpages>4</tpages></addata></record> |
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| subjects | Administration, Oral Alstonia Animals Biological and medical sciences Body Weight Drug toxicity and drugs side effects treatment Infertility, Male - drug therapy Male Medical sciences Organ Size Pharmacology. Drug treatments Plant Bark Plant Extracts - pharmacology Rats Rats, Wistar Spermatozoa - drug effects Testis - drug effects Toxicity: urogenital system Tropical medicine 作用机理 夹竹桃 提取物 精子活性 |
| title | Effect of Alstonia Scholaris bark extract on testicular function of Wistar rats |
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