Pathogenesis and treatment of pain caused by skin metastases in neuroendocrine tumours
Prognosis of neuroendocrine tumours has improved during the last decade and one might expect that more patients with (sub)cutaneous metastases will be seen in the future. We investigated the cause of pain in skin metastases and tried to give recommendations about treatment options. We compared histo...
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| Veröffentlicht in: | Netherlands journal of medicine 2002-06, Vol.60 (5), p.207-211 |
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| container_title | Netherlands journal of medicine |
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| creator | ZUETENHORST, J. M VAN VELTHUYSEN, M. L. F RUTGERS, E. J. Th BOOT, H TAAL, B. G |
| description | Prognosis of neuroendocrine tumours has improved during the last decade and one might expect that more patients with (sub)cutaneous metastases will be seen in the future. We investigated the cause of pain in skin metastases and tried to give recommendations about treatment options.
We compared histology of (sub)cutaneous metastases in four patients, two with severely painful skin lesions and two without pain.
On the pathological slides there were no differences in neuroinvasion, angioinvasion or mitosis between painful and non-painful metastases. However, the painful metastases rapidly multiplied, while the others remained indolent in nature. Pain was very difficult to manage and did not respond to analgesics, irradiation or systemic treatment with interferon or chemotherapy. Local excision was the only successful treatment option.
Histology did not show differences between painful and non-painful skin metastases. Local excision is the treatment of choice. |
| format | Article |
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We compared histology of (sub)cutaneous metastases in four patients, two with severely painful skin lesions and two without pain.
On the pathological slides there were no differences in neuroinvasion, angioinvasion or mitosis between painful and non-painful metastases. However, the painful metastases rapidly multiplied, while the others remained indolent in nature. Pain was very difficult to manage and did not respond to analgesics, irradiation or systemic treatment with interferon or chemotherapy. Local excision was the only successful treatment option.
Histology did not show differences between painful and non-painful skin metastases. Local excision is the treatment of choice.</description><identifier>ISSN: 0300-2977</identifier><identifier>EISSN: 1872-9061</identifier><identifier>PMID: 12365476</identifier><language>eng</language><publisher>Alphen aan den Rijn: Van zuiden</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoid Tumor - pathology ; Dermatology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Pain, Intractable - etiology ; Pain, Intractable - therapy ; Skin - pathology ; Skin Neoplasms - pathology ; Skin Neoplasms - physiopathology ; Skin Neoplasms - secondary ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Netherlands journal of medicine, 2002-06, Vol.60 (5), p.207-211</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13722775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12365476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZUETENHORST, J. M</creatorcontrib><creatorcontrib>VAN VELTHUYSEN, M. L. F</creatorcontrib><creatorcontrib>RUTGERS, E. J. Th</creatorcontrib><creatorcontrib>BOOT, H</creatorcontrib><creatorcontrib>TAAL, B. G</creatorcontrib><title>Pathogenesis and treatment of pain caused by skin metastases in neuroendocrine tumours</title><title>Netherlands journal of medicine</title><addtitle>Neth J Med</addtitle><description>Prognosis of neuroendocrine tumours has improved during the last decade and one might expect that more patients with (sub)cutaneous metastases will be seen in the future. We investigated the cause of pain in skin metastases and tried to give recommendations about treatment options.
We compared histology of (sub)cutaneous metastases in four patients, two with severely painful skin lesions and two without pain.
On the pathological slides there were no differences in neuroinvasion, angioinvasion or mitosis between painful and non-painful metastases. However, the painful metastases rapidly multiplied, while the others remained indolent in nature. Pain was very difficult to manage and did not respond to analgesics, irradiation or systemic treatment with interferon or chemotherapy. Local excision was the only successful treatment option.
Histology did not show differences between painful and non-painful skin metastases. Local excision is the treatment of choice.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoid Tumor - pathology</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pain, Intractable - etiology</subject><subject>Pain, Intractable - therapy</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - physiopathology</subject><subject>Skin Neoplasms - secondary</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0300-2977</issn><issn>1872-9061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LxDAQBuAgiruu_gXJRW-FJE2TzVEWv2BBD-q1TNOpVtu0ZtLD_nsLVoSB4YWHl2GO2FpurcqcMPKYrUUuRKactSt2RvQphDDWFadsJVVuCm3Nmr09Q_oY3jEgtcQh1DxFhNRjSHxo-Aht4B4mwppXB05fc-wxAc2DxOcUcIoDhnrwsQ3I09QPU6RzdtJAR3ix7A17vbt92T1k-6f7x93NPhtVblM2nyOhQinB1tJYrbXxriiarXG1N96Acw4V5pVWNTSgnFYGVaW9LBpX6SbfsOvf3jEO3xNSKvuWPHYdBBwmKq2ShXBbN8PLBU5Vj3U5xraHeCj_PjGDqwUAeeiaCMG39O9yq5S1Rf4DioBpKw</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>ZUETENHORST, J. M</creator><creator>VAN VELTHUYSEN, M. L. F</creator><creator>RUTGERS, E. J. Th</creator><creator>BOOT, H</creator><creator>TAAL, B. G</creator><general>Van zuiden</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Pathogenesis and treatment of pain caused by skin metastases in neuroendocrine tumours</title><author>ZUETENHORST, J. M ; VAN VELTHUYSEN, M. L. F ; RUTGERS, E. J. Th ; BOOT, H ; TAAL, B. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-6791abe11a7d1674446c955f869dc6c6a999e2e3b42dafa29426e2b4c15f9b4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoid Tumor - pathology</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pain, Intractable - etiology</topic><topic>Pain, Intractable - therapy</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - physiopathology</topic><topic>Skin Neoplasms - secondary</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZUETENHORST, J. M</creatorcontrib><creatorcontrib>VAN VELTHUYSEN, M. L. F</creatorcontrib><creatorcontrib>RUTGERS, E. J. Th</creatorcontrib><creatorcontrib>BOOT, H</creatorcontrib><creatorcontrib>TAAL, B. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Netherlands journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZUETENHORST, J. M</au><au>VAN VELTHUYSEN, M. L. F</au><au>RUTGERS, E. J. Th</au><au>BOOT, H</au><au>TAAL, B. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathogenesis and treatment of pain caused by skin metastases in neuroendocrine tumours</atitle><jtitle>Netherlands journal of medicine</jtitle><addtitle>Neth J Med</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>60</volume><issue>5</issue><spage>207</spage><epage>211</epage><pages>207-211</pages><issn>0300-2977</issn><eissn>1872-9061</eissn><abstract>Prognosis of neuroendocrine tumours has improved during the last decade and one might expect that more patients with (sub)cutaneous metastases will be seen in the future. We investigated the cause of pain in skin metastases and tried to give recommendations about treatment options.
We compared histology of (sub)cutaneous metastases in four patients, two with severely painful skin lesions and two without pain.
On the pathological slides there were no differences in neuroinvasion, angioinvasion or mitosis between painful and non-painful metastases. However, the painful metastases rapidly multiplied, while the others remained indolent in nature. Pain was very difficult to manage and did not respond to analgesics, irradiation or systemic treatment with interferon or chemotherapy. Local excision was the only successful treatment option.
Histology did not show differences between painful and non-painful skin metastases. Local excision is the treatment of choice.</abstract><cop>Alphen aan den Rijn</cop><pub>Van zuiden</pub><pmid>12365476</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Netherlands journal of medicine, 2002-06, Vol.60 (5), p.207-211 |
| issn | 0300-2977 1872-9061 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Carcinoid Tumor - pathology Dermatology Female Humans Male Medical sciences Middle Aged Pain, Intractable - etiology Pain, Intractable - therapy Skin - pathology Skin Neoplasms - pathology Skin Neoplasms - physiopathology Skin Neoplasms - secondary Tumors of the skin and soft tissue. Premalignant lesions |
| title | Pathogenesis and treatment of pain caused by skin metastases in neuroendocrine tumours |
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