Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase

The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach is described below. The initial pyrazole-containing lead compounds were optimized for potency against Helicobacter pylori DHODase. Using three...

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Veröffentlicht in:	Journal of medicinal chemistry 2002-10, Vol.45 (21), p.4669-4678
Hauptverfasser:	HAQUE, Tasir S., TADESSE, Seifu, MARCINKEVICIENE, Jovita, ROGERS, M. John, SIZEMORE, Christine, KOPCHO, Lisa M., AMSLER, Karen, ECRET, Lisa D., ZHAN, Dong Liang, HOBBS, Frank, SLEE, Andrew, TRAINOR, George L., STERN, Andrew M., COPELAND, Robert A., COMBS, Andrew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Combinatorial Chemistry Techniques Digestive system Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Helicobacter pylori Helicobacter pylori - drug effects Helicobacter pylori - enzymology Humans Medical sciences Oxidoreductases - antagonists & inhibitors Pharmacology. Drug treatments Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Structure-Activity Relationship
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