A Receptor Tyrosine Kinase cDNA Isolated from a Population of Enriched Primitive Hematopoietic Cells and Exhibiting Close Genetic Linkage to C-kit

We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-10, Vol.88 (20), p.9026-9030
Hauptverfasser:	Matthews, William, Jordan, Craig T., Gavin, Marc, Jenkins, Nancy A., Copeland, Neal G., Lemischka, Ihor R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Base Sequence Biological and medical sciences Chromosome Mapping Complementary DNA Crosses, Genetic DNA - genetics DNA - isolation & purification Female Fetus Fundamental and applied biological sciences. Psychology Gene Expression Genes Genes. Genome Genetic Linkage Genetic loci Hematopoietic stem cells Hematopoietic Stem Cells - enzymology Liver Liver - physiology Male Messenger RNA Mice Mice, Inbred C57BL Molecular and cellular biology Molecular genetics Molecular Sequence Data Multigene Family Muridae Polymerase Chain Reaction Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-kit Proto-Oncogenes Receptors Receptors, Cell Surface - genetics RNA RNA, Messenger - genetics Sequence Homology, Nucleic Acid Totipotent stem cells
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