In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus

The effects of cis-3,4 dichloro- N-2-(l-pyrrolidinyl)cyclo-hexyl-benzamide (U-54494A), an anticonvulsant related to kappa opioids, were studied in vitro on the extracellular electrical activity of the CA1 region of slices of hippocampus in the rat. The effects of U-54494A were compared to those of t...

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Veröffentlicht in:	Neuropharmacology 1991-06, Vol.30 (6), p.637-642
Hauptverfasser:	Proietti, M.L., De Carolis, A.Sctti, Frank, C., Zeng, Y.C., Sagratella, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer Analgesics - pharmacology Animals Anticonvulsants - pharmacology Azocines - pharmacology Calcium - metabolism calcium ions Cell Membrane - drug effects Cell Membrane - metabolism Depression, Chemical Electric Stimulation Female field potentials hippocampal slices Hippocampus - drug effects In Vitro Techniques kappa opioids Membrane Potentials - drug effects Naltrexone - pharmacology Narcotic Antagonists - pharmacology Neurons - drug effects Neurons - metabolism Pyrrolidines - pharmacology Rats Rats, Inbred Strains Receptors, Opioid - drug effects Receptors, Opioid, kappa Synapses - drug effects Synaptic Transmission - drug effects
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