Generation of Velogenic Newcastle Disease Viruses from a Nonpathogenic Waterfowl Isolate by Passaging in Chickens

A benign Newcastle disease virus (NDV) recently became highly virulent during replication in domestic chickens. It is still unclear whether NDVs circulating among wild waterfowl also have the potential to become highly pathogenic (velogenic) in chickens. To demonstrate experimentally the generation...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2002-09, Vol.301 (2), p.206-211
Hauptverfasser:	Shengqing, Yu, Kishida, Noriko, Ito, Hiroshi, Kida, Hiroshi, Otsuki, Koichi, Kawaoka, Yoshihiro, Ito, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Wild - virology Binding Sites chicken Chickens cleavage Geese - virology NDV Newcastle Disease - virology Newcastle disease virus - isolation & purification Newcastle disease virus - pathogenicity Newcastle disease virus - physiology pathogenicity Sequence Analysis, DNA Trypsin Viral Fusion Proteins - genetics Viral Plaque Assay waterfowl
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