Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting

Tumor vasculature can be targeted by peptides containing an RGD (Arg–Gly–Asp) sequence, which bind to α vβ 3 and α vβ 5 integrins on angiogenic endothelial cells. By covalently attaching cyclic RGD-peptides (cRGDfK) to a protein backbone, we prepared a multivalent peptide–protein conjugate with incr...

Ausführliche Beschreibung