Increased circulating normal and BCR-ABL+Ve progenitor numbers in Philadelphia chromosome-positive acute myeloid leukaemia

We recorded elevated numbers of circulating myeloid and erythroid colony-forming cells in 15 adult patients with acute myeloid leukaemia (AML) who presented with high blood white cell counts. Since leukaemic blasts from three of these patients were Philadelphia chromosome-positive (Ph+), we were abl...

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Veröffentlicht in:	Leukemia research 2002-11, Vol.26 (11), p.997-1005
Hauptverfasser:	Baines, Paul, Austin, Steve, Fisher, Janet, Owen-Jones, Eleri, Lee-Jones, Lisa, Throp, Duncan, Mckinley, Mark, Hoy, Terry, Mills, Ken, Thompson, Peter W, Burnett, Alan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult AML BCR-ABL Biomarkers, Tumor Case-Control Studies Colony-forming progenitors Colony-Forming Units Assay DNA, Neoplasm - analysis Erythroid Precursor Cells - metabolism FISH Flow Cytometry Fusion Proteins, bcr-abl - blood Fusion Proteins, bcr-abl - genetics Genes, Immunoglobulin - genetics Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukocyte Count Myeloid Progenitor Cells - metabolism Oncogene Proteins - genetics Oncogene Proteins - metabolism Protein-Tyrosine Kinases Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcr Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Neoplasm - genetics RNA, Neoplasm - metabolism RT-PCR
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