Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice
The cyclic expression of matrix metalloproteinases (MMPs) by human endometrium has been suggested to play a role in the invasive process necessary to establish endometriosis. The ability of progesterone exposure to inhibit endometrial MMP-3 and MMP-7 expression requires the local action of TGFβ and...
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Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2002-10, Vol.87 (10), p.4782-4791 |
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creator | Bruner-Tran, Kaylon L. Eisenberg, Esther Yeaman, Grant R. Anderson, Ted A. McBean, Judith Osteen, Kevin G. |
description | The cyclic expression of matrix metalloproteinases (MMPs) by human endometrium has been suggested to play a role in the invasive process necessary to establish endometriosis. The ability of progesterone exposure to inhibit endometrial MMP-3 and MMP-7 expression requires the local action of TGFβ and may also be linked to the local production of retinoic acid by stromal cells. A continuous expression of several MMPs in endometriotic lesions has been reported, indicating a failure of progesterone or locally produced factors to suppress these enzymes. To address cell-specific MMP regulation associated with endometriosis, we examined expression of MMP-3 and MMP-7 mRNA in eutopic endometrium and endometriotic lesions acquired during the secretory phase of the menstrual cycle. We examined the in vitro regulation of MMP-3 and MMP-7 protein in similar tissues. We also examined the in vitro regulation of MMP secretion by progesterone, retinoic acid, and TGFβ in endometriosis tissues relative to the establishment of experimental disease. Our studies indicate that either eutopic or ectopic tissue from women with endometriosis exhibit patterns of altered MMP regulation in vivo. A lack of responsiveness to progesterone was demonstrated in vitro, associated with a failure to suppress MMP expression and an enhanced ability of the tissue to establish experimental endometriosis. However, in vitro treatments with retinoic acid and TGFβ restored the ability of progesterone to suppress MMPs in vitro and prevented the establishment of experimental disease. |
doi_str_mv | 10.1210/jc.2002-020418 |
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The ability of progesterone exposure to inhibit endometrial MMP-3 and MMP-7 expression requires the local action of TGFβ and may also be linked to the local production of retinoic acid by stromal cells. A continuous expression of several MMPs in endometriotic lesions has been reported, indicating a failure of progesterone or locally produced factors to suppress these enzymes. To address cell-specific MMP regulation associated with endometriosis, we examined expression of MMP-3 and MMP-7 mRNA in eutopic endometrium and endometriotic lesions acquired during the secretory phase of the menstrual cycle. We examined the in vitro regulation of MMP-3 and MMP-7 protein in similar tissues. We also examined the in vitro regulation of MMP secretion by progesterone, retinoic acid, and TGFβ in endometriosis tissues relative to the establishment of experimental disease. Our studies indicate that either eutopic or ectopic tissue from women with endometriosis exhibit patterns of altered MMP regulation in vivo. A lack of responsiveness to progesterone was demonstrated in vitro, associated with a failure to suppress MMP expression and an enhanced ability of the tissue to establish experimental endometriosis. However, in vitro treatments with retinoic acid and TGFβ restored the ability of progesterone to suppress MMPs in vitro and prevented the establishment of experimental disease.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2002-020418</identifier><identifier>PMID: 12364474</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adolescent ; Adult ; Animals ; Biological and medical sciences ; Endometriosis - enzymology ; Endometrium - enzymology ; Estradiol - pharmacology ; Female ; Female genital diseases ; Gene Expression Regulation - drug effects ; Gynecology. Andrology. Obstetrics ; Humans ; In Situ Hybridization ; Matrix Metalloproteinase 3 - genetics ; Matrix Metalloproteinase 7 - genetics ; Medical sciences ; Metalloendopeptidases - genetics ; Metalloendopeptidases - metabolism ; Mice ; Mice, Nude ; Middle Aged ; Non tumoral diseases ; Organ Culture Techniques ; Progesterone - pharmacology ; RNA, Messenger - analysis ; Transforming Growth Factor beta - pharmacology ; Tretinoin - pharmacology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2002-10, Vol.87 (10), p.4782-4791</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-8512af267fe13f34647fc56614faed8741932116dc46593b3ed207da0f3eb7033</citedby><cites>FETCH-LOGICAL-c407t-8512af267fe13f34647fc56614faed8741932116dc46593b3ed207da0f3eb7033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13959219$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12364474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bruner-Tran, Kaylon L.</creatorcontrib><creatorcontrib>Eisenberg, Esther</creatorcontrib><creatorcontrib>Yeaman, Grant R.</creatorcontrib><creatorcontrib>Anderson, Ted A.</creatorcontrib><creatorcontrib>McBean, Judith</creatorcontrib><creatorcontrib>Osteen, Kevin G.</creatorcontrib><title>Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>The cyclic expression of matrix metalloproteinases (MMPs) by human endometrium has been suggested to play a role in the invasive process necessary to establish endometriosis. The ability of progesterone exposure to inhibit endometrial MMP-3 and MMP-7 expression requires the local action of TGFβ and may also be linked to the local production of retinoic acid by stromal cells. A continuous expression of several MMPs in endometriotic lesions has been reported, indicating a failure of progesterone or locally produced factors to suppress these enzymes. To address cell-specific MMP regulation associated with endometriosis, we examined expression of MMP-3 and MMP-7 mRNA in eutopic endometrium and endometriotic lesions acquired during the secretory phase of the menstrual cycle. We examined the in vitro regulation of MMP-3 and MMP-7 protein in similar tissues. We also examined the in vitro regulation of MMP secretion by progesterone, retinoic acid, and TGFβ in endometriosis tissues relative to the establishment of experimental disease. Our studies indicate that either eutopic or ectopic tissue from women with endometriosis exhibit patterns of altered MMP regulation in vivo. A lack of responsiveness to progesterone was demonstrated in vitro, associated with a failure to suppress MMP expression and an enhanced ability of the tissue to establish experimental endometriosis. However, in vitro treatments with retinoic acid and TGFβ restored the ability of progesterone to suppress MMPs in vitro and prevented the establishment of experimental disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Endometriosis - enzymology</subject><subject>Endometrium - enzymology</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Matrix Metalloproteinase 3 - genetics</subject><subject>Matrix Metalloproteinase 7 - genetics</subject><subject>Medical sciences</subject><subject>Metalloendopeptidases - genetics</subject><subject>Metalloendopeptidases - metabolism</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Organ Culture Techniques</subject><subject>Progesterone - pharmacology</subject><subject>RNA, Messenger - analysis</subject><subject>Transforming Growth Factor beta - pharmacology</subject><subject>Tretinoin - pharmacology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1qGzEUhUVpaBy32y6LNu1uHP3NyLMsxmkDcQttA9kNsnTVyJUlV9JA8iZ93GpiQ6DQlbjoO4d7z0HoLSULyii53OkFI4Q1hBFBly_QjPaibSTt5Us0qx-06SW7O0cXOe8IoUK0_BU6p4x3QkgxQ3--F0jRGayCwavHEn-5APgb_By9Ki4GHC3eqJLcA95AUd7HQ4oFXFAZ8PrhkCDnCXMBr4OJe6hozC4_-ZX7yuSitt7l-z2EMrlVESQ3Tcr_o6kmX0YDeOM0vEZnVvkMb07vHN1erX-sPjc3Xz9drz7eNFoQWZplS5myrJMWKLdcdEJa3XYdFVaBWUpBe84o7YwWXdvzLQfDiDSKWA5bSTifow9H33rX7xFyGfYua_BeBYhjHiSjQta4Krg4gjrFnBPY4VDPUOlxoGSYuhh2epi6GI5dVMG7k_O43YN5xk_hV-D9CVBZK2-TCtrlZ473bc_q_nPUHjmoaelUC3qKfdjFMYWazf8W-AupAqXf</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Bruner-Tran, Kaylon L.</creator><creator>Eisenberg, Esther</creator><creator>Yeaman, Grant R.</creator><creator>Anderson, Ted A.</creator><creator>McBean, Judith</creator><creator>Osteen, Kevin G.</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice</title><author>Bruner-Tran, Kaylon L. ; Eisenberg, Esther ; Yeaman, Grant R. ; Anderson, Ted A. ; McBean, Judith ; Osteen, Kevin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-8512af267fe13f34647fc56614faed8741932116dc46593b3ed207da0f3eb7033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Endometriosis - enzymology</topic><topic>Endometrium - enzymology</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Matrix Metalloproteinase 3 - genetics</topic><topic>Matrix Metalloproteinase 7 - genetics</topic><topic>Medical sciences</topic><topic>Metalloendopeptidases - genetics</topic><topic>Metalloendopeptidases - metabolism</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Organ Culture Techniques</topic><topic>Progesterone - pharmacology</topic><topic>RNA, Messenger - analysis</topic><topic>Transforming Growth Factor beta - pharmacology</topic><topic>Tretinoin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bruner-Tran, Kaylon L.</creatorcontrib><creatorcontrib>Eisenberg, Esther</creatorcontrib><creatorcontrib>Yeaman, Grant R.</creatorcontrib><creatorcontrib>Anderson, Ted A.</creatorcontrib><creatorcontrib>McBean, Judith</creatorcontrib><creatorcontrib>Osteen, Kevin G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bruner-Tran, Kaylon L.</au><au>Eisenberg, Esther</au><au>Yeaman, Grant R.</au><au>Anderson, Ted A.</au><au>McBean, Judith</au><au>Osteen, Kevin G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>87</volume><issue>10</issue><spage>4782</spage><epage>4791</epage><pages>4782-4791</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>The cyclic expression of matrix metalloproteinases (MMPs) by human endometrium has been suggested to play a role in the invasive process necessary to establish endometriosis. The ability of progesterone exposure to inhibit endometrial MMP-3 and MMP-7 expression requires the local action of TGFβ and may also be linked to the local production of retinoic acid by stromal cells. A continuous expression of several MMPs in endometriotic lesions has been reported, indicating a failure of progesterone or locally produced factors to suppress these enzymes. To address cell-specific MMP regulation associated with endometriosis, we examined expression of MMP-3 and MMP-7 mRNA in eutopic endometrium and endometriotic lesions acquired during the secretory phase of the menstrual cycle. We examined the in vitro regulation of MMP-3 and MMP-7 protein in similar tissues. We also examined the in vitro regulation of MMP secretion by progesterone, retinoic acid, and TGFβ in endometriosis tissues relative to the establishment of experimental disease. Our studies indicate that either eutopic or ectopic tissue from women with endometriosis exhibit patterns of altered MMP regulation in vivo. A lack of responsiveness to progesterone was demonstrated in vitro, associated with a failure to suppress MMP expression and an enhanced ability of the tissue to establish experimental endometriosis. However, in vitro treatments with retinoic acid and TGFβ restored the ability of progesterone to suppress MMPs in vitro and prevented the establishment of experimental disease.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>12364474</pmid><doi>10.1210/jc.2002-020418</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Animals Biological and medical sciences Endometriosis - enzymology Endometrium - enzymology Estradiol - pharmacology Female Female genital diseases Gene Expression Regulation - drug effects Gynecology. Andrology. Obstetrics Humans In Situ Hybridization Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 7 - genetics Medical sciences Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Mice Mice, Nude Middle Aged Non tumoral diseases Organ Culture Techniques Progesterone - pharmacology RNA, Messenger - analysis Transforming Growth Factor beta - pharmacology Tretinoin - pharmacology |
title | Steroid and Cytokine Regulation of Matrix Metalloproteinase Expression in Endometriosis and the Establishment of Experimental Endometriosis in Nude Mice |
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