Homoazanicotine: A Structure-Affinity Study for Nicotinic Acetylcholine (nACh) Receptor Binding

We have recently identified 3-[(1-methyl)-4,5-dihydro-1H-imidazol-2-yl)methyl]pyridine (homoazanicotine, 8) as a novel nicotinic acetylcholinergic (nACh) receptor ligand. In the present investigation, after we determined that 8 binds selectively at nicotinic (K i = 7.8 nM) vs muscarinic (K i > 10...

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Veröffentlicht in:	Journal of medicinal chemistry 2002-10, Vol.45 (21), p.4724-4731
Hauptverfasser:	Ferretti, G, Dukat, M, Giannella, M, Piergentili, A, Pigini, M, Quaglia, W, Damaj, M. I, Martin, B. R, Glennon, R. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - chemical synthesis Acetamides - chemistry Acetamides - pharmacology Animals Biological and medical sciences Cholinergic system Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Ligands Male Medical sciences Mice Mice, Inbred ICR Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Nicotine - analogs & derivatives Nicotine - chemical synthesis Nicotine - chemistry Nicotine - pharmacology Pain Measurement Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Nicotinic - metabolism Structure-Activity Relationship
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