Reactor Operation and Scale-Up of Whole Cell Baeyer-Villiger Catalyzed Lactone Synthesis

The recombinant whole cell biocatalyst Escherichia coli TOP10 [pQR239], expressing cyclohexanone monooxygenase from Acinetobacter calcoaceticus NCIMB 9871, was used in 1.5‐ and 55‐L fed‐batch processes to oxidize bicyclo[3.2.0]hept‐2‐en‐6‐one to its corresponding regioisomeric lactones, (–)‐(1 S,5 R...

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Veröffentlicht in:	Biotechnology progress 2002, Vol.18 (5), p.1039-1046
Hauptverfasser:	Doig, Steven D., Avenell, Philip J., Bird, Paul A., Gallati, Patrick, Lander, Katie S., Lye, Gary J., Wohlgemuth, Roland, Woodley, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter calcoaceticus - classification Acinetobacter calcoaceticus - genetics Acinetobacter calcoaceticus - metabolism Biological and medical sciences Bioreactors Bridged Bicyclo Compounds - metabolism Catalysis Cell Line Escherichia coli - classification Escherichia coli - genetics Escherichia coli - metabolism Flavoproteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Ketones - metabolism Lactones - metabolism Mixed Function Oxygenases - metabolism Oxidation-Reduction Oxygen - metabolism Oxygenases - metabolism Pilot Projects Quality Control Recombinant Proteins Recombination, Genetic Sensitivity and Specificity Species Specificity Stereoisomerism
Online-Zugang:	Volltext
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