Intravitreal Injection of Adeno-associated Viral Vectors Results in the Transduction of Different Types of Retinal Neurons in Neonatal and Adult Rats: A Comparison with Lentiviral Vectors

Replication-deficient viral vectors encoding the marker gene green fluorescent protein (GFP) were injected into the vitreous of newborn, juvenile (P14), and adult rats. We tested two different types of modified virus: adeno-associated viral-2–GFP (AAV-GFP) and lentiviral–GFP vectors (LV-GFP). The ex...

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Veröffentlicht in:	Molecular and cellular neuroscience 2002-09, Vol.21 (1), p.141-157
Hauptverfasser:	Harvey, A.R., Kamphuis, W., Eggers, R., Symons, N.A., Blits, B., Niclou, S., Boer, G.J., Verhaagen, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Age Factors Animals Animals, Newborn Axons - physiology Female Genetic Vectors Green Fluorescent Proteins Immunohistochemistry Indicators and Reagents - metabolism Lentivirus - genetics Luminescent Proteins - genetics Phenotype Pregnancy Rats Rats, Wistar Retinal Ganglion Cells - physiology Retinal Ganglion Cells - ultrastructure Transduction, Genetic - methods Transgenes - genetics Visual Pathways - cytology Vitreous Body
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