Angiotensin II Constriction of Rat Vasa Recta Is Partially Thromboxane Dependent

ABSTRACT—We tested the hypothesis that thromboxane generation mediates vasoconstriction of isolated outer medullary descending vasa recta (OMDVR) by angiotensin (Ang) II. The lipoxygenase and cyclooxygenase (COX) inhibitor eicosatetraynoic acid (1 μmol/L) and the COX inhibitor indomethacin (1 μmol/L...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-10, Vol.40 (4), p.541-546
Hauptverfasser:	Silldorff, Erik P, Hilbun, Layla R, Pallone, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology 5,8,11,14-Eicosatetraynoic Acid - pharmacology Angiotensin II - antagonists & inhibitors Angiotensin II - pharmacology Animals Benzofurans - pharmacology Biological and medical sciences Blood Vessels - drug effects Blood Vessels - physiology Blood vessels and receptors Bridged Bicyclo Compounds, Heterocyclic Culture Techniques Cyclooxygenase Inhibitors - pharmacology Enzyme Inhibitors - pharmacology Fatty Acids, Unsaturated Female Fundamental and applied biological sciences. Psychology Hydrazines - pharmacology Indomethacin - pharmacology Kidney Medulla - blood supply Kidney Medulla - physiology Kinetics Lipoxygenase Inhibitors - pharmacology Potassium Chloride - antagonists & inhibitors Rats Rats, Sprague-Dawley Receptors, Thromboxane - antagonists & inhibitors Thromboxane-A Synthase - antagonists & inhibitors Thromboxanes - physiology Vasoconstriction - drug effects Vasoconstrictor Agents - antagonists & inhibitors Vasoconstrictor Agents - pharmacology Vertebrates: cardiovascular system
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