Kinetics and biodistribution in relation to tumour detection with 111In-labelled OV-TL 3 F(ab')2 in patients with ovarian cancer
The biological behaviour of 111In-labelled OV-TL 3 F(ab')2 was studied in 22 patients with suspected ovarian cancer. After i.v. injection with 140 MBq 111In-OV-TL 3 F(ab')2 (1 mg) blood samples were taken up to 96 h and urine and faeces were collected throughout the whole study. At surgery...
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| Veröffentlicht in: | Nuclear medicine communications 1991-07, Vol.12 (7), p.593-609 |
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| creator | MASSUGER, L. F. A. G CLAESSENS, R. A. M. J KENEMANS P VERHEIJEN, R. H. M BOERMAN, O. C MEEUWIS, A. P. W SCHIJF, C. P. T BUIJS, W. C. A. M HANSELAAR, T. G. J. M CORSTENS, F. H. M |
| description | The biological behaviour of 111In-labelled OV-TL 3 F(ab')2 was studied in 22 patients with suspected ovarian cancer. After i.v. injection with 140 MBq 111In-OV-TL 3 F(ab')2 (1 mg) blood samples were taken up to 96 h and urine and faeces were collected throughout the whole study. At surgery, 5 to 7 days post-injection, primary and metastatic tumour tissues, as well as fragments of several normal tissues, were removed and 111In uptake was measured. Blood activity disappeared with half-life values of 6.1 +/- 1.1 and 17.9 +/- 6.5 h. Within 96 h excretion in urine and faeces was 16.1 +/- 2.0% i.d. (mean +/- S.D.) and 3.1 +/- 1.9% i.d., respectively. Mean tissue uptake, expressed as % i.d. kg-1 was 3.9 +/- 1.0 for primary tumour, 11.5 +/- 5.0 for liver and 0.4 +/- 0.1 for several normal background tissues. Higher tumour uptake correlated with a higher detection rate at immunoscintigraphy. However, no strict correlation was found between the amount of tumour uptake and the expression of the monoclonal antibody defined OA3 antigen. Quantitation of organ activity, using region of interest analysis, resulted in mean peak organ activities for the liver of 16% i.d., spleen 9% i.d. and kidney 4% i.d. Distribution data indicate that besides specific antibody-antigen interaction several other mechanisms play a role in uptake in tumour and other tissues. |
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F. A. G ; CLAESSENS, R. A. M. J ; KENEMANS P ; VERHEIJEN, R. H. M ; BOERMAN, O. C ; MEEUWIS, A. P. W ; SCHIJF, C. P. T ; BUIJS, W. C. A. M ; HANSELAAR, T. G. J. M ; CORSTENS, F. H. M</creator><creatorcontrib>MASSUGER, L. F. A. G ; CLAESSENS, R. A. M. J ; KENEMANS P ; VERHEIJEN, R. H. M ; BOERMAN, O. C ; MEEUWIS, A. P. W ; SCHIJF, C. P. T ; BUIJS, W. C. A. M ; HANSELAAR, T. G. J. M ; CORSTENS, F. H. M</creatorcontrib><description>The biological behaviour of 111In-labelled OV-TL 3 F(ab')2 was studied in 22 patients with suspected ovarian cancer. After i.v. injection with 140 MBq 111In-OV-TL 3 F(ab')2 (1 mg) blood samples were taken up to 96 h and urine and faeces were collected throughout the whole study. At surgery, 5 to 7 days post-injection, primary and metastatic tumour tissues, as well as fragments of several normal tissues, were removed and 111In uptake was measured. Blood activity disappeared with half-life values of 6.1 +/- 1.1 and 17.9 +/- 6.5 h. Within 96 h excretion in urine and faeces was 16.1 +/- 2.0% i.d. (mean +/- S.D.) and 3.1 +/- 1.9% i.d., respectively. Mean tissue uptake, expressed as % i.d. kg-1 was 3.9 +/- 1.0 for primary tumour, 11.5 +/- 5.0 for liver and 0.4 +/- 0.1 for several normal background tissues. Higher tumour uptake correlated with a higher detection rate at immunoscintigraphy. However, no strict correlation was found between the amount of tumour uptake and the expression of the monoclonal antibody defined OA3 antigen. Quantitation of organ activity, using region of interest analysis, resulted in mean peak organ activities for the liver of 16% i.d., spleen 9% i.d. and kidney 4% i.d. Distribution data indicate that besides specific antibody-antigen interaction several other mechanisms play a role in uptake in tumour and other tissues.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>PMID: 1923151</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Antibodies, Monoclonal - metabolism ; Biological and medical sciences ; Endocrine glands. Genital system. Mammary gland ; Female ; Humans ; Indium Radioisotopes ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Ovarian Neoplasms - diagnostic imaging ; Ovarian Neoplasms - metabolism ; Radioimmunodetection ; Radionuclide investigations ; Rats ; Rats, Inbred Strains ; Tissue Distribution</subject><ispartof>Nuclear medicine communications, 1991-07, Vol.12 (7), p.593-609</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5395821$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1923151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MASSUGER, L. F. A. G</creatorcontrib><creatorcontrib>CLAESSENS, R. A. M. J</creatorcontrib><creatorcontrib>KENEMANS P</creatorcontrib><creatorcontrib>VERHEIJEN, R. H. M</creatorcontrib><creatorcontrib>BOERMAN, O. C</creatorcontrib><creatorcontrib>MEEUWIS, A. P. W</creatorcontrib><creatorcontrib>SCHIJF, C. P. T</creatorcontrib><creatorcontrib>BUIJS, W. C. A. M</creatorcontrib><creatorcontrib>HANSELAAR, T. G. J. M</creatorcontrib><creatorcontrib>CORSTENS, F. H. M</creatorcontrib><title>Kinetics and biodistribution in relation to tumour detection with 111In-labelled OV-TL 3 F(ab')2 in patients with ovarian cancer</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>The biological behaviour of 111In-labelled OV-TL 3 F(ab')2 was studied in 22 patients with suspected ovarian cancer. After i.v. injection with 140 MBq 111In-OV-TL 3 F(ab')2 (1 mg) blood samples were taken up to 96 h and urine and faeces were collected throughout the whole study. At surgery, 5 to 7 days post-injection, primary and metastatic tumour tissues, as well as fragments of several normal tissues, were removed and 111In uptake was measured. Blood activity disappeared with half-life values of 6.1 +/- 1.1 and 17.9 +/- 6.5 h. Within 96 h excretion in urine and faeces was 16.1 +/- 2.0% i.d. (mean +/- S.D.) and 3.1 +/- 1.9% i.d., respectively. Mean tissue uptake, expressed as % i.d. kg-1 was 3.9 +/- 1.0 for primary tumour, 11.5 +/- 5.0 for liver and 0.4 +/- 0.1 for several normal background tissues. Higher tumour uptake correlated with a higher detection rate at immunoscintigraphy. However, no strict correlation was found between the amount of tumour uptake and the expression of the monoclonal antibody defined OA3 antigen. Quantitation of organ activity, using region of interest analysis, resulted in mean peak organ activities for the liver of 16% i.d., spleen 9% i.d. and kidney 4% i.d. Distribution data indicate that besides specific antibody-antigen interaction several other mechanisms play a role in uptake in tumour and other tissues.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Biological and medical sciences</subject><subject>Endocrine glands. Genital system. Mammary gland</subject><subject>Female</subject><subject>Humans</subject><subject>Indium Radioisotopes</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Ovarian Neoplasms - diagnostic imaging</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Radioimmunodetection</subject><subject>Radionuclide investigations</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tissue Distribution</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LxDAQxYMo67r6EYQcxD-HQtM0TXqUxdXFhb0sXss0mWKkTWuSKt786NZ18TTDvB-P9-aIzFkueSKKTB2TecpynvCCF6fkLIS3NE0VL-SMzFiZcSbYnHw_W4fR6kDBGVrb3tgQva3HaHtHraMeW9jvsadx7PrRU4MR9f72aeMrZYytXdJCjW2Lhm5fkt2Gcrq6hfrmLvv1GCYHdDH88f0HeAuOanAa_Tk5aaANeHGYC7JbPeyWT8lm-7he3m-SQWUsyRBBCS2B10zmAmqDjWasaZTE2oDIBapMA0ChlUxRiUZzqZUxoik4loIvyPWf7eD79xFDrDob9JQYHPZjqGTG8rxU5QReHsCx7tBUg7cd-K_q8LFJvzroEDS0jZ9a2PCPCV6KKTD_ATShdkc</recordid><startdate>199107</startdate><enddate>199107</enddate><creator>MASSUGER, L. 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M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p821-2eea85c7a3b1745abdefc11ff87ebda545e82caaa6c870e85fc37c8dd5f63e953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>Biological and medical sciences</topic><topic>Endocrine glands. Genital system. Mammary gland</topic><topic>Female</topic><topic>Humans</topic><topic>Indium Radioisotopes</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Ovarian Neoplasms - diagnostic imaging</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Radioimmunodetection</topic><topic>Radionuclide investigations</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MASSUGER, L. F. A. G</creatorcontrib><creatorcontrib>CLAESSENS, R. A. M. J</creatorcontrib><creatorcontrib>KENEMANS P</creatorcontrib><creatorcontrib>VERHEIJEN, R. H. M</creatorcontrib><creatorcontrib>BOERMAN, O. C</creatorcontrib><creatorcontrib>MEEUWIS, A. P. W</creatorcontrib><creatorcontrib>SCHIJF, C. P. T</creatorcontrib><creatorcontrib>BUIJS, W. C. A. M</creatorcontrib><creatorcontrib>HANSELAAR, T. G. J. M</creatorcontrib><creatorcontrib>CORSTENS, F. H. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MASSUGER, L. F. A. G</au><au>CLAESSENS, R. A. M. J</au><au>KENEMANS P</au><au>VERHEIJEN, R. H. M</au><au>BOERMAN, O. C</au><au>MEEUWIS, A. P. W</au><au>SCHIJF, C. P. T</au><au>BUIJS, W. C. A. M</au><au>HANSELAAR, T. G. J. M</au><au>CORSTENS, F. H. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics and biodistribution in relation to tumour detection with 111In-labelled OV-TL 3 F(ab')2 in patients with ovarian cancer</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>1991-07</date><risdate>1991</risdate><volume>12</volume><issue>7</issue><spage>593</spage><epage>609</epage><pages>593-609</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>The biological behaviour of 111In-labelled OV-TL 3 F(ab')2 was studied in 22 patients with suspected ovarian cancer. After i.v. injection with 140 MBq 111In-OV-TL 3 F(ab')2 (1 mg) blood samples were taken up to 96 h and urine and faeces were collected throughout the whole study. At surgery, 5 to 7 days post-injection, primary and metastatic tumour tissues, as well as fragments of several normal tissues, were removed and 111In uptake was measured. Blood activity disappeared with half-life values of 6.1 +/- 1.1 and 17.9 +/- 6.5 h. Within 96 h excretion in urine and faeces was 16.1 +/- 2.0% i.d. (mean +/- S.D.) and 3.1 +/- 1.9% i.d., respectively. Mean tissue uptake, expressed as % i.d. kg-1 was 3.9 +/- 1.0 for primary tumour, 11.5 +/- 5.0 for liver and 0.4 +/- 0.1 for several normal background tissues. Higher tumour uptake correlated with a higher detection rate at immunoscintigraphy. However, no strict correlation was found between the amount of tumour uptake and the expression of the monoclonal antibody defined OA3 antigen. Quantitation of organ activity, using region of interest analysis, resulted in mean peak organ activities for the liver of 16% i.d., spleen 9% i.d. and kidney 4% i.d. Distribution data indicate that besides specific antibody-antigen interaction several other mechanisms play a role in uptake in tumour and other tissues.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>1923151</pmid><tpages>17</tpages></addata></record> |
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| ispartof | Nuclear medicine communications, 1991-07, Vol.12 (7), p.593-609 |
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| subjects | Animals Antibodies, Monoclonal - metabolism Biological and medical sciences Endocrine glands. Genital system. Mammary gland Female Humans Indium Radioisotopes Investigative techniques, diagnostic techniques (general aspects) Medical sciences Ovarian Neoplasms - diagnostic imaging Ovarian Neoplasms - metabolism Radioimmunodetection Radionuclide investigations Rats Rats, Inbred Strains Tissue Distribution |
| title | Kinetics and biodistribution in relation to tumour detection with 111In-labelled OV-TL 3 F(ab')2 in patients with ovarian cancer |
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