Iontophoretic application of NMDA produces different types of excitatory responses in developing human cortical and caudate neurons
The effects of iontophoretically applied N- methyl- d-aspartate (NMDA) were assessed in human neocortical and caudate neurons. NMDA depolarized cell membranes, decreased input conductances and induced firing. The discharge patterns differed in the two areas studied. In neocortex, NMDA produced repet...
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| Veröffentlicht in: | Neuroscience letters 1991-05, Vol.126 (2), p.167-171 |
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| creator | Cepeda, Carlos Peacock, Warwick Levine, Michael S. Buchwald, Nathaniel A. |
| description | The effects of iontophoretically applied
N-
methyl-
d-aspartate
(NMDA) were assessed in human neocortical and caudate neurons. NMDA depolarized cell membranes, decreased input conductances and induced firing. The discharge patterns differed in the two areas studied. In neocortex, NMDA produced repetitive spikes or bursts. In caudate, it induced slow, rhythmic plateau depolarizations accompanied by an initial burst of action potentials, followed by low amplitude, long duration spikes. Afterhyperpolarizations were seen after each depolarization in the caudate. These variations in patterns of excitation may relate to differences in local circuits intrinsic to each region, and/or to membrane conductances specific to each type of cell. |
| doi_str_mv | 10.1016/0304-3940(91)90545-5 |
| format | Article |
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N-
methyl-
d-aspartate
(NMDA) were assessed in human neocortical and caudate neurons. NMDA depolarized cell membranes, decreased input conductances and induced firing. The discharge patterns differed in the two areas studied. In neocortex, NMDA produced repetitive spikes or bursts. In caudate, it induced slow, rhythmic plateau depolarizations accompanied by an initial burst of action potentials, followed by low amplitude, long duration spikes. Afterhyperpolarizations were seen after each depolarization in the caudate. These variations in patterns of excitation may relate to differences in local circuits intrinsic to each region, and/or to membrane conductances specific to each type of cell.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(91)90545-5</identifier><identifier>PMID: 1922927</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Aging - physiology ; Biological and medical sciences ; Caudate ; Caudate Nucleus - cytology ; Caudate Nucleus - growth & development ; Caudate Nucleus - physiology ; Central nervous system ; Cerebral Cortex - cytology ; Cerebral Cortex - growth & development ; Cerebral Cortex - physiology ; Child ; Child, Preschool ; Development ; Electrophysiology ; Epilepsy ; Fundamental and applied biological sciences. Psychology ; Human ; Humans ; In Vitro Techniques ; Infant ; Iontophoresis ; N-Methylaspartate - pharmacology ; Neocortex ; Neurons - drug effects ; Neurons - physiology ; NMDA ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1991-05, Vol.126 (2), p.167-171</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-3874b5484ab55017981ee40dae8a03df62fac9a2e99868313043b01ff1bf972c3</citedby><cites>FETCH-LOGICAL-c418t-3874b5484ab55017981ee40dae8a03df62fac9a2e99868313043b01ff1bf972c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304394091905455$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19780992$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1922927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cepeda, Carlos</creatorcontrib><creatorcontrib>Peacock, Warwick</creatorcontrib><creatorcontrib>Levine, Michael S.</creatorcontrib><creatorcontrib>Buchwald, Nathaniel A.</creatorcontrib><title>Iontophoretic application of NMDA produces different types of excitatory responses in developing human cortical and caudate neurons</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The effects of iontophoretically applied
N-
methyl-
d-aspartate
(NMDA) were assessed in human neocortical and caudate neurons. NMDA depolarized cell membranes, decreased input conductances and induced firing. The discharge patterns differed in the two areas studied. In neocortex, NMDA produced repetitive spikes or bursts. In caudate, it induced slow, rhythmic plateau depolarizations accompanied by an initial burst of action potentials, followed by low amplitude, long duration spikes. Afterhyperpolarizations were seen after each depolarization in the caudate. These variations in patterns of excitation may relate to differences in local circuits intrinsic to each region, and/or to membrane conductances specific to each type of cell.</description><subject>Adolescent</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Caudate</subject><subject>Caudate Nucleus - cytology</subject><subject>Caudate Nucleus - growth & development</subject><subject>Caudate Nucleus - physiology</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - growth & development</subject><subject>Cerebral Cortex - physiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Development</subject><subject>Electrophysiology</subject><subject>Epilepsy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Infant</subject><subject>Iontophoresis</subject><subject>N-Methylaspartate - pharmacology</subject><subject>Neocortex</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>NMDA</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vFSEUxYnR1NfqN9CEjaYuRoGBx7AxaVr_NKm60TVh4GIx82AEpulb94vL872oq7oicH_nXu45CD2j5DUldP2G9IR3veLkVNFXigguOvEAreggWSeVZA_R6g_yGB2X8oMQIqjgR-iIKsYUkyt0d5liTfN1ylCDxWaep2BNDSni5PHnTxdneM7JLRYKdsF7yBArrtu53RsAtzZUU1Pe4gxlTrG09xCxgxuY0hzid3y9bEzENuXW30zYRIetWZypgCMsuUmeoEfeTAWeHs4T9O39u6_nH7urLx8uz8-uOsvpULt-kHwUfOBmFIJQqQYKwIkzMBjSO79m3lhlGCg1rIeett37kVDv6eibHbY_QS_3fdtGPxcoVW9CsTBNJkJaipaM8l4R-V-QCiWEZKyBfA_anErJ4PWcw8bkraZE70LSuwT0LgGtqP4dkhZN9vzQfxk34P6K9qm0-otD3ZTmmc8m2lD-weRAlNqNf7vnoLl2EyDrYgNECy5ksFW7FO7_yC9Gvq-_</recordid><startdate>19910527</startdate><enddate>19910527</enddate><creator>Cepeda, Carlos</creator><creator>Peacock, Warwick</creator><creator>Levine, Michael S.</creator><creator>Buchwald, Nathaniel A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910527</creationdate><title>Iontophoretic application of NMDA produces different types of excitatory responses in developing human cortical and caudate neurons</title><author>Cepeda, Carlos ; Peacock, Warwick ; Levine, Michael S. ; Buchwald, Nathaniel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-3874b5484ab55017981ee40dae8a03df62fac9a2e99868313043b01ff1bf972c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Caudate</topic><topic>Caudate Nucleus - cytology</topic><topic>Caudate Nucleus - growth & development</topic><topic>Caudate Nucleus - physiology</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - growth & development</topic><topic>Cerebral Cortex - physiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Development</topic><topic>Electrophysiology</topic><topic>Epilepsy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Infant</topic><topic>Iontophoresis</topic><topic>N-Methylaspartate - pharmacology</topic><topic>Neocortex</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>NMDA</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cepeda, Carlos</creatorcontrib><creatorcontrib>Peacock, Warwick</creatorcontrib><creatorcontrib>Levine, Michael S.</creatorcontrib><creatorcontrib>Buchwald, Nathaniel A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cepeda, Carlos</au><au>Peacock, Warwick</au><au>Levine, Michael S.</au><au>Buchwald, Nathaniel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iontophoretic application of NMDA produces different types of excitatory responses in developing human cortical and caudate neurons</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1991-05-27</date><risdate>1991</risdate><volume>126</volume><issue>2</issue><spage>167</spage><epage>171</epage><pages>167-171</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The effects of iontophoretically applied
N-
methyl-
d-aspartate
(NMDA) were assessed in human neocortical and caudate neurons. NMDA depolarized cell membranes, decreased input conductances and induced firing. The discharge patterns differed in the two areas studied. In neocortex, NMDA produced repetitive spikes or bursts. In caudate, it induced slow, rhythmic plateau depolarizations accompanied by an initial burst of action potentials, followed by low amplitude, long duration spikes. Afterhyperpolarizations were seen after each depolarization in the caudate. These variations in patterns of excitation may relate to differences in local circuits intrinsic to each region, and/or to membrane conductances specific to each type of cell.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1922927</pmid><doi>10.1016/0304-3940(91)90545-5</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1991-05, Vol.126 (2), p.167-171 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Aging - physiology Biological and medical sciences Caudate Caudate Nucleus - cytology Caudate Nucleus - growth & development Caudate Nucleus - physiology Central nervous system Cerebral Cortex - cytology Cerebral Cortex - growth & development Cerebral Cortex - physiology Child Child, Preschool Development Electrophysiology Epilepsy Fundamental and applied biological sciences. Psychology Human Humans In Vitro Techniques Infant Iontophoresis N-Methylaspartate - pharmacology Neocortex Neurons - drug effects Neurons - physiology NMDA Vertebrates: nervous system and sense organs |
| title | Iontophoretic application of NMDA produces different types of excitatory responses in developing human cortical and caudate neurons |
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