Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study

Neurotensin (NT) and neuromedin N (NN) are generated by endoproteolytic cleavage of a common precursor molecule, pro‐NT/NN. To gain insight into the role of prohormone convertases PC1, PC2, and PC7 in this process, we investigated the maturation of pro‐NT/NN in the brain of PC7 (PC7−/–), PC2 (PC2–/–...

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Veröffentlicht in:	Journal of neurochemistry 2002-08, Vol.82 (4), p.783-793
Hauptverfasser:	Villeneuve, Pierre, Feliciangeli, Sylvain, Croissandeau, Gilles, Seidah, Nabil G., Mbikay, Majambu, Kitabgi, Patrick, Beaudet, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid Endopeptidases - genetics Brain - cytology Brain - metabolism Brain Chemistry endoproteolysis Heterozygote Homozygote Hypothalamus - cytology Hypothalamus - metabolism Immunohistochemistry Mice Mice, Knockout neuropeptides prohormone convertases Neurotensin - metabolism Peptide Fragments - analysis Peptide Fragments - metabolism peptide processing Proprotein Convertase 1 Proprotein Convertase 2 Proprotein Convertases Protein Precursors - metabolism Protein Processing, Post-Translational Radioimmunoassay subtilisin Subtilisins - deficiency Subtilisins - genetics
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