Prediction of intestinal absorption: comparative assessment of gastroplus™ and idea

We have assessed two commercial software tools employing physiologically based models for prediction of intestinal absorption in human. idea™ 2.0 and gastroplus™ 3.1.0 were compared both in their ability to predict fraction absorbed for a set of 28 drugs and in terms of the functionality offered. Th...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2002-10, Vol.17 (1), p.51-61
Hauptverfasser:	Parrott, Neil, Lavé, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	ADME Biological and medical sciences General pharmacology Intestinal Absorption - physiology Medical sciences Modeling Oral absorption Pharmaceutical Preparations - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Physiologically based pharmacokinetics Predictive Value of Tests Simulation Software - statistics & numerical data
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