Elevated Homocysteine Levels in Young Male Patients With Schizophrenia
OBJECTIVE: Elevated plasma homocysteine has been found to be a risk factor for Alzheimer's disease as well as cerebral vascular disease, suggesting that some risk factors can accelerate or increase the severity of several CNS disease processes. The authors measured plasma homocysteine levels in...
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| Veröffentlicht in: | The American journal of psychiatry 2002-10, Vol.159 (10), p.1790-1792 |
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| container_issue | 10 |
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| container_title | The American journal of psychiatry |
| container_volume | 159 |
| creator | Levine, Joseph Stahl, Ziva Sela, Ben Ami Gavendo, Slava Ruderman, Vladimir Belmaker, Robert H. |
| description | OBJECTIVE: Elevated plasma homocysteine has been found to be a risk factor for Alzheimer's disease as well as cerebral vascular disease, suggesting that some risk factors can accelerate or increase the severity of several CNS disease processes. The authors measured plasma homocysteine levels in patients with chronic schizophrenia in their catchment area. METHOD: A one-way analysis of covariance with age and sex as covariates was performed on the total plasma homocysteine levels of 193 patients with schizophrenia compared with 762 subjects without the diagnosis of schizophrenia who were evaluated in a screening program for employee health. RESULTS: The effect of schizophrenia was marked: the mean homocysteine level was 16.3 M (SD=11.8) in patients with schizophrenia compared with 10.6 M (SD=3.6) in healthy comparison subjects. The difference between groups was almost entirely attributable to the homocysteine levels of young male patients with schizophrenia. CONCLUSIONS: Elevated levels of homocysteine in young male patients with schizophrenia could be related to the pathophysiology of aspects of this illness. |
| doi_str_mv | 10.1176/appi.ajp.159.10.1790 |
| format | Article |
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The authors measured plasma homocysteine levels in patients with chronic schizophrenia in their catchment area. METHOD: A one-way analysis of covariance with age and sex as covariates was performed on the total plasma homocysteine levels of 193 patients with schizophrenia compared with 762 subjects without the diagnosis of schizophrenia who were evaluated in a screening program for employee health. RESULTS: The effect of schizophrenia was marked: the mean homocysteine level was 16.3 M (SD=11.8) in patients with schizophrenia compared with 10.6 M (SD=3.6) in healthy comparison subjects. The difference between groups was almost entirely attributable to the homocysteine levels of young male patients with schizophrenia. CONCLUSIONS: Elevated levels of homocysteine in young male patients with schizophrenia could be related to the pathophysiology of aspects of this illness.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.159.10.1790</identifier><identifier>PMID: 12359692</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Age Factors ; Aged ; Analysis of Variance ; Biological and medical sciences ; Chronic Disease ; Female ; Health risk assessment ; Homocysteine - blood ; Homocysteine - physiology ; Humans ; Male ; Medical sciences ; Men ; Middle Aged ; Plasma ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - diagnosis ; Schizophrenia - physiopathology ; Sex Factors</subject><ispartof>The American journal of psychiatry, 2002-10, Vol.159 (10), p.1790-1792</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Oct 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a402t-52ef9546d14a50abe3385f050b1acda91d4c21b108c945004a7928116d7a757d3</citedby><cites>FETCH-LOGICAL-a402t-52ef9546d14a50abe3385f050b1acda91d4c21b108c945004a7928116d7a757d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.159.10.1790$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.159.10.1790$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2853,21625,21626,21627,27923,27924,77565,77570</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13959626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12359692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levine, Joseph</creatorcontrib><creatorcontrib>Stahl, Ziva</creatorcontrib><creatorcontrib>Sela, Ben Ami</creatorcontrib><creatorcontrib>Gavendo, Slava</creatorcontrib><creatorcontrib>Ruderman, Vladimir</creatorcontrib><creatorcontrib>Belmaker, Robert H.</creatorcontrib><title>Elevated Homocysteine Levels in Young Male Patients With Schizophrenia</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: Elevated plasma homocysteine has been found to be a risk factor for Alzheimer's disease as well as cerebral vascular disease, suggesting that some risk factors can accelerate or increase the severity of several CNS disease processes. The authors measured plasma homocysteine levels in patients with chronic schizophrenia in their catchment area. METHOD: A one-way analysis of covariance with age and sex as covariates was performed on the total plasma homocysteine levels of 193 patients with schizophrenia compared with 762 subjects without the diagnosis of schizophrenia who were evaluated in a screening program for employee health. RESULTS: The effect of schizophrenia was marked: the mean homocysteine level was 16.3 M (SD=11.8) in patients with schizophrenia compared with 10.6 M (SD=3.6) in healthy comparison subjects. The difference between groups was almost entirely attributable to the homocysteine levels of young male patients with schizophrenia. CONCLUSIONS: Elevated levels of homocysteine in young male patients with schizophrenia could be related to the pathophysiology of aspects of this illness.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Homocysteine - blood</subject><subject>Homocysteine - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Plasma</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - physiopathology</subject><subject>Sex Factors</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9L3EAQxxep6FX7HxQJQvuWc_ZX9vZRRGvhpIKK9mmZ20x6e-SSNJsI9q_vnndU8KFPwwyfmfnyYewzhynnpjjDrgtTXHVTru10MzQW9tiEa6lzI8TsA5sAgMitlk-H7GOMq9SCNOKAHXIhtS2smLCry5qecaAyu27XrX-JA4WGsjk9Ux2z0GQ_27H5ld1gTdktDoGaIWaPYVhmd34Z_rTdsqcm4DHbr7CO9GlXj9jD1eX9xXU-__Ht-8X5PEcFYsi1oMpqVZRcoQZckJQzXYGGBUdfouWl8oIvOMy8VRpAobFixnlRGjTalPKIfd3e7fr290hxcOsQPdU1NtSO0RnBFRhlE3j6Dly1Y9-kbE4IUAUIKROktpDv2xh7qlzXhzX2L46D20h2G8kuSXZJ8uswSU5rJ7vb42JN5dvSzmoCvuwAjB7rqsfGh_jGSZs4USSOb7nXN_8C_vf5X5HDlXg</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Levine, Joseph</creator><creator>Stahl, Ziva</creator><creator>Sela, Ben Ami</creator><creator>Gavendo, Slava</creator><creator>Ruderman, Vladimir</creator><creator>Belmaker, Robert H.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Elevated Homocysteine Levels in Young Male Patients With Schizophrenia</title><author>Levine, Joseph ; Stahl, Ziva ; Sela, Ben Ami ; Gavendo, Slava ; Ruderman, Vladimir ; Belmaker, Robert H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a402t-52ef9546d14a50abe3385f050b1acda91d4c21b108c945004a7928116d7a757d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Homocysteine - blood</topic><topic>Homocysteine - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Plasma</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - physiopathology</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levine, Joseph</creatorcontrib><creatorcontrib>Stahl, Ziva</creatorcontrib><creatorcontrib>Sela, Ben Ami</creatorcontrib><creatorcontrib>Gavendo, Slava</creatorcontrib><creatorcontrib>Ruderman, Vladimir</creatorcontrib><creatorcontrib>Belmaker, Robert H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levine, Joseph</au><au>Stahl, Ziva</au><au>Sela, Ben Ami</au><au>Gavendo, Slava</au><au>Ruderman, Vladimir</au><au>Belmaker, Robert H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Homocysteine Levels in Young Male Patients With Schizophrenia</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>159</volume><issue>10</issue><spage>1790</spage><epage>1792</epage><pages>1790-1792</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: Elevated plasma homocysteine has been found to be a risk factor for Alzheimer's disease as well as cerebral vascular disease, suggesting that some risk factors can accelerate or increase the severity of several CNS disease processes. The authors measured plasma homocysteine levels in patients with chronic schizophrenia in their catchment area. METHOD: A one-way analysis of covariance with age and sex as covariates was performed on the total plasma homocysteine levels of 193 patients with schizophrenia compared with 762 subjects without the diagnosis of schizophrenia who were evaluated in a screening program for employee health. RESULTS: The effect of schizophrenia was marked: the mean homocysteine level was 16.3 M (SD=11.8) in patients with schizophrenia compared with 10.6 M (SD=3.6) in healthy comparison subjects. The difference between groups was almost entirely attributable to the homocysteine levels of young male patients with schizophrenia. CONCLUSIONS: Elevated levels of homocysteine in young male patients with schizophrenia could be related to the pathophysiology of aspects of this illness.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>12359692</pmid><doi>10.1176/appi.ajp.159.10.1790</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Adult and adolescent clinical studies Age Factors Aged Analysis of Variance Biological and medical sciences Chronic Disease Female Health risk assessment Homocysteine - blood Homocysteine - physiology Humans Male Medical sciences Men Middle Aged Plasma Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - blood Schizophrenia - diagnosis Schizophrenia - physiopathology Sex Factors |
| title | Elevated Homocysteine Levels in Young Male Patients With Schizophrenia |
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