Effect of Carbon-11-Acetate Recirculation on Estimates of Myocardial Oxygen Consumption by PET
Mono- and biexponential fitting of myocardial 11C-acetate kinetics does not account for the effect of recirculating 11C activity following intravenous injection of the tracer. A tracer kinetic model comprising two and three compartments was developed to describe intravascular and myocardial 11C-acet...
Gespeichert in:
| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1991-10, Vol.32 (10), p.1950-1957 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1957 |
|---|---|
| container_issue | 10 |
| container_start_page | 1950 |
| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 32 |
| creator | Buck, Alfred Wolpers, H. Georg Hutchins, Gary D Savas, Vicky Mangner, Thomas J Nguyen, Ngoc Schwaiger, Markus |
| description | Mono- and biexponential fitting of myocardial 11C-acetate kinetics does not account for the effect of recirculating 11C activity following intravenous injection of the tracer. A tracer kinetic model comprising two and three compartments was developed to describe intravascular and myocardial 11C-acetate kinetics defined by PET. This model approach including a correction for 11C-metabolites in blood was validated by correlating the model parameter estimates with directly measured oxygen consumption (MVO2) in 11 closed-chest dog experiments over a wide range of cardiac work. The model parameter k2 closely correlated with oxygen consumption (r = 0.94). This approach was subsequently applied to human studies and k2-related to rate-pressure product (PRP). In comparison to conventional monoexponential fitting of 11C-acetate tissue kinetics, the model approach improved the correlation coefficients of scintigraphic MVO2 estimates and PRP values from 0.61 to 0.91. Thus, analysis of myocardial 11C-acetate and clearance kinetics with a tracer kinetic model corrects for recirculating 11C-activity and may provide more consistent estimates of myocardial oxygen consumption. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72140606</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72140606</sourcerecordid><originalsourceid>FETCH-LOGICAL-h239t-5b810e1d95bf15dc1eebc281aedcc092c35e5798865160b50aff8160e01f4fcd3</originalsourceid><addsrcrecordid>eNot0G1LwzAQB_AgypzTjyD0lfgmkGuXNH05Sn2AyUTmW0uSXtaOPsykRfvt7dzg4A7-Pw7uLsgceMQpFyK-JHMGAijnjF-TG-_3jDEhpZyRGSSQxJGck6_MWjR90NkgVU53LQWgK4O96jH4QFM5M9Sqr7o2mCrzfdVMiT_6t7EzyhWVqoPN77jDNki71g_N4V_rMXjPtrfkyqra4925L8jnU7ZNX-h68_yarta0DKOkp1xLYAhFwrUFXhhA1CaUoLAwhiWhiTjyOJFScBBMc6asldOEDOzSmiJakIfT3oPrvgf0fd5U3mBdqxa7wedxCEsmmJjg_RkOusEiP7jpIDfm54dM-eMpL6td-VM5zNvB1KjcEe_bJgpzYJPmLPoDS4NrQw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72140606</pqid></control><display><type>article</type><title>Effect of Carbon-11-Acetate Recirculation on Estimates of Myocardial Oxygen Consumption by PET</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Buck, Alfred ; Wolpers, H. Georg ; Hutchins, Gary D ; Savas, Vicky ; Mangner, Thomas J ; Nguyen, Ngoc ; Schwaiger, Markus</creator><creatorcontrib>Buck, Alfred ; Wolpers, H. Georg ; Hutchins, Gary D ; Savas, Vicky ; Mangner, Thomas J ; Nguyen, Ngoc ; Schwaiger, Markus</creatorcontrib><description>Mono- and biexponential fitting of myocardial 11C-acetate kinetics does not account for the effect of recirculating 11C activity following intravenous injection of the tracer. A tracer kinetic model comprising two and three compartments was developed to describe intravascular and myocardial 11C-acetate kinetics defined by PET. This model approach including a correction for 11C-metabolites in blood was validated by correlating the model parameter estimates with directly measured oxygen consumption (MVO2) in 11 closed-chest dog experiments over a wide range of cardiac work. The model parameter k2 closely correlated with oxygen consumption (r = 0.94). This approach was subsequently applied to human studies and k2-related to rate-pressure product (PRP). In comparison to conventional monoexponential fitting of 11C-acetate tissue kinetics, the model approach improved the correlation coefficients of scintigraphic MVO2 estimates and PRP values from 0.61 to 0.91. Thus, analysis of myocardial 11C-acetate and clearance kinetics with a tracer kinetic model corrects for recirculating 11C-activity and may provide more consistent estimates of myocardial oxygen consumption.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 1919738</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Acetates ; Adult ; Animals ; Carbon Radioisotopes ; Dogs ; Female ; Heart - diagnostic imaging ; Heart Valve Diseases - diagnostic imaging ; Humans ; Male ; Middle Aged ; Models, Theoretical ; Myocardium - metabolism ; Oxygen Consumption - physiology ; Tomography, Emission-Computed</subject><ispartof>The Journal of nuclear medicine (1978), 1991-10, Vol.32 (10), p.1950-1957</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1919738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buck, Alfred</creatorcontrib><creatorcontrib>Wolpers, H. Georg</creatorcontrib><creatorcontrib>Hutchins, Gary D</creatorcontrib><creatorcontrib>Savas, Vicky</creatorcontrib><creatorcontrib>Mangner, Thomas J</creatorcontrib><creatorcontrib>Nguyen, Ngoc</creatorcontrib><creatorcontrib>Schwaiger, Markus</creatorcontrib><title>Effect of Carbon-11-Acetate Recirculation on Estimates of Myocardial Oxygen Consumption by PET</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Mono- and biexponential fitting of myocardial 11C-acetate kinetics does not account for the effect of recirculating 11C activity following intravenous injection of the tracer. A tracer kinetic model comprising two and three compartments was developed to describe intravascular and myocardial 11C-acetate kinetics defined by PET. This model approach including a correction for 11C-metabolites in blood was validated by correlating the model parameter estimates with directly measured oxygen consumption (MVO2) in 11 closed-chest dog experiments over a wide range of cardiac work. The model parameter k2 closely correlated with oxygen consumption (r = 0.94). This approach was subsequently applied to human studies and k2-related to rate-pressure product (PRP). In comparison to conventional monoexponential fitting of 11C-acetate tissue kinetics, the model approach improved the correlation coefficients of scintigraphic MVO2 estimates and PRP values from 0.61 to 0.91. Thus, analysis of myocardial 11C-acetate and clearance kinetics with a tracer kinetic model corrects for recirculating 11C-activity and may provide more consistent estimates of myocardial oxygen consumption.</description><subject>Acetates</subject><subject>Adult</subject><subject>Animals</subject><subject>Carbon Radioisotopes</subject><subject>Dogs</subject><subject>Female</subject><subject>Heart - diagnostic imaging</subject><subject>Heart Valve Diseases - diagnostic imaging</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Theoretical</subject><subject>Myocardium - metabolism</subject><subject>Oxygen Consumption - physiology</subject><subject>Tomography, Emission-Computed</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNot0G1LwzAQB_AgypzTjyD0lfgmkGuXNH05Sn2AyUTmW0uSXtaOPsykRfvt7dzg4A7-Pw7uLsgceMQpFyK-JHMGAijnjF-TG-_3jDEhpZyRGSSQxJGck6_MWjR90NkgVU53LQWgK4O96jH4QFM5M9Sqr7o2mCrzfdVMiT_6t7EzyhWVqoPN77jDNki71g_N4V_rMXjPtrfkyqra4925L8jnU7ZNX-h68_yarta0DKOkp1xLYAhFwrUFXhhA1CaUoLAwhiWhiTjyOJFScBBMc6asldOEDOzSmiJakIfT3oPrvgf0fd5U3mBdqxa7wedxCEsmmJjg_RkOusEiP7jpIDfm54dM-eMpL6td-VM5zNvB1KjcEe_bJgpzYJPmLPoDS4NrQw</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>Buck, Alfred</creator><creator>Wolpers, H. Georg</creator><creator>Hutchins, Gary D</creator><creator>Savas, Vicky</creator><creator>Mangner, Thomas J</creator><creator>Nguyen, Ngoc</creator><creator>Schwaiger, Markus</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19911001</creationdate><title>Effect of Carbon-11-Acetate Recirculation on Estimates of Myocardial Oxygen Consumption by PET</title><author>Buck, Alfred ; Wolpers, H. Georg ; Hutchins, Gary D ; Savas, Vicky ; Mangner, Thomas J ; Nguyen, Ngoc ; Schwaiger, Markus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h239t-5b810e1d95bf15dc1eebc281aedcc092c35e5798865160b50aff8160e01f4fcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acetates</topic><topic>Adult</topic><topic>Animals</topic><topic>Carbon Radioisotopes</topic><topic>Dogs</topic><topic>Female</topic><topic>Heart - diagnostic imaging</topic><topic>Heart Valve Diseases - diagnostic imaging</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Theoretical</topic><topic>Myocardium - metabolism</topic><topic>Oxygen Consumption - physiology</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buck, Alfred</creatorcontrib><creatorcontrib>Wolpers, H. Georg</creatorcontrib><creatorcontrib>Hutchins, Gary D</creatorcontrib><creatorcontrib>Savas, Vicky</creatorcontrib><creatorcontrib>Mangner, Thomas J</creatorcontrib><creatorcontrib>Nguyen, Ngoc</creatorcontrib><creatorcontrib>Schwaiger, Markus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buck, Alfred</au><au>Wolpers, H. Georg</au><au>Hutchins, Gary D</au><au>Savas, Vicky</au><au>Mangner, Thomas J</au><au>Nguyen, Ngoc</au><au>Schwaiger, Markus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Carbon-11-Acetate Recirculation on Estimates of Myocardial Oxygen Consumption by PET</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>32</volume><issue>10</issue><spage>1950</spage><epage>1957</epage><pages>1950-1957</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>Mono- and biexponential fitting of myocardial 11C-acetate kinetics does not account for the effect of recirculating 11C activity following intravenous injection of the tracer. A tracer kinetic model comprising two and three compartments was developed to describe intravascular and myocardial 11C-acetate kinetics defined by PET. This model approach including a correction for 11C-metabolites in blood was validated by correlating the model parameter estimates with directly measured oxygen consumption (MVO2) in 11 closed-chest dog experiments over a wide range of cardiac work. The model parameter k2 closely correlated with oxygen consumption (r = 0.94). This approach was subsequently applied to human studies and k2-related to rate-pressure product (PRP). In comparison to conventional monoexponential fitting of 11C-acetate tissue kinetics, the model approach improved the correlation coefficients of scintigraphic MVO2 estimates and PRP values from 0.61 to 0.91. Thus, analysis of myocardial 11C-acetate and clearance kinetics with a tracer kinetic model corrects for recirculating 11C-activity and may provide more consistent estimates of myocardial oxygen consumption.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>1919738</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-5505 |
| ispartof | The Journal of nuclear medicine (1978), 1991-10, Vol.32 (10), p.1950-1957 |
| issn | 0161-5505 1535-5667 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72140606 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acetates Adult Animals Carbon Radioisotopes Dogs Female Heart - diagnostic imaging Heart Valve Diseases - diagnostic imaging Humans Male Middle Aged Models, Theoretical Myocardium - metabolism Oxygen Consumption - physiology Tomography, Emission-Computed |
| title | Effect of Carbon-11-Acetate Recirculation on Estimates of Myocardial Oxygen Consumption by PET |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T14%3A42%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Carbon-11-Acetate%20Recirculation%20on%20Estimates%20of%20Myocardial%20Oxygen%20Consumption%20by%20PET&rft.jtitle=The%20Journal%20of%20nuclear%20medicine%20(1978)&rft.au=Buck,%20Alfred&rft.date=1991-10-01&rft.volume=32&rft.issue=10&rft.spage=1950&rft.epage=1957&rft.pages=1950-1957&rft.issn=0161-5505&rft.eissn=1535-5667&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E72140606%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72140606&rft_id=info:pmid/1919738&rfr_iscdi=true |