Monoclonal antibodies to the leukocyte common antigen (CD45) inhibit IgE-mediated histamine release from human basophils

mAb were selected that inhibited IgE-mediated histamine release from human basophils. The two mAb, HB 9AB6 and HB 10AB2, are of the IgG1 subclass and have a 50% inhibitory concentration of 0.16 to 1.1 micrograms/ml. The mAb required several hours of incubation with the basophils at 37 degrees C to i...

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Veröffentlicht in:	The Journal of immunology (1950) 1991-10, Vol.147 (8), p.2670-2676
Hauptverfasser:	Hook, WA, Berenstein, EH, Zinsser, FU, Fischler, C, Siraganian, RP
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Antigens, CD - immunology Antigens, CD - physiology Antigens, Differentiation, B-Lymphocyte - physiology Basophils - metabolism Biological and medical sciences Cell physiology Cells, Cultured Fundamental and applied biological sciences. Psychology Histamine Release Histocompatibility Antigens - immunology Histocompatibility Antigens - physiology Humans Immunoglobulin E - physiology Leukocyte Common Antigens Molecular and cellular biology Phosphorylation Receptors, Fc - physiology Receptors, IgE Signal transduction Tyrosine - metabolism
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