Cytokine-induced IL-1 beta gene expression in the human polymorphonuclear leukocyte: transcriptional and post-transcriptional regulation by tumor necrosis factor and IL-1

We have previously demonstrated that Il-1 and TNF could rapidly, but transiently, induce gene expression of Il-1 beta in human polymorphonuclear leukocytes (PMN) at both the protein and mRNA level. Additionally, we demonstrated a cooperative effect of Il-1 and TNF on the kinetics of induction of Il-...

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Veröffentlicht in:	The Journal of immunology (1950) 1991-10, Vol.147 (8), p.2603-2608
Hauptverfasser:	Marucha, PT, Zeff, RA, Kreutzer, DL
Format:	Artikel
Sprache:	eng
Schlagworte:	Cycloheximide - pharmacology Gene Expression Regulation - drug effects Half-Life Humans Interleukin-1 - genetics Interleukin-1 - pharmacology Neutrophils - metabolism RNA, Messenger - analysis RNA, Messenger - metabolism Transcription, Genetic - drug effects Tumor Necrosis Factor-alpha - pharmacology
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