In vivo skin penetration of salicylic compounds in hairless rats

The in vivo skin penetration of four salicylic compounds was investigated using a hairless rat model, which allowed for non-occluded, finite dose application, and free mobility of the rats throughout the test period. The model compounds were applied in equimolal concentrations of 0.4 mmol/g dimethyl...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2002-10, Vol.17 (1), p.95-104
Hauptverfasser:	Simonsen, Lene, Petersen, Mads B, Groth, Lotte
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animal model Animals Biological and medical sciences Female In vitro permeation In Vitro Techniques In vitro–in vivo Medical sciences Neuropharmacology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Salicylates Salicylates - chemistry Salicylates - pharmacokinetics Skin Absorption - physiology Skin penetration Topical application
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