Humoral immune functions in IL-4 transgenic mice

We have analyzed mice expressing IL-4 as a transgene, and found that expression of this lymphokine has profound effects on B cell function. B cells from transgenic mice exhibit phenotypic changes, including an increase in size and elevated expression of class II MHC. IL-4 increases the quantity of I...

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Veröffentlicht in:	The Journal of immunology (1950) 1991-11, Vol.147 (9), p.2950-2956
Hauptverfasser:	Burstein, HJ, Tepper, RI, Leder, P, Abbas, AK
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Antibody Formation Antibody production Antigens, Differentiation, B-Lymphocyte - analysis Antigens, T-Independent - immunology B-Lymphocyte Subsets - immunology Biological and medical sciences Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Interleukin-4 - physiology Mice Mice, Transgenic - immunology Trinitrobenzenes - immunology
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