Successful treatment of congenital thrombotic thrombocytopenic purpura using the intermediate purity factor VIII concentrate BPL 8Y

There is increasing evidence that congenital thrombotic thrombocytopenic purpura (TTP) is caused by an absolute deficiency of von Willebrand factor‐cleaving protease. The recent identification of this protease and the development of assays for its detection have enabled its quantification in a numbe...

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Veröffentlicht in:	British journal of haematology 2002-10, Vol.119 (1), p.176-179
Hauptverfasser:	Lester, Will A., Williams, Michael D., Allford, Sarah L., Enayat, M. Said, Machin, Samuel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antigens - blood Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system congenital thrombotic thrombocytopenic purpura Factor VIII - therapeutic use Female fresh‐frozen plasma Hematologic and hematopoietic diseases Hematology Humans intermediate purity factor VIII concentrate L-Lactate Dehydrogenase - blood Medical sciences microangiopathy Pharmacology. Drug treatments Platelet Count Platelet diseases and coagulopathies Purpura, Thrombotic Thrombocytopenic - congenital Purpura, Thrombotic Thrombocytopenic - therapy Treatment Outcome von Willebrand Factor - immunology von Willebrand factor‐cleaving protease
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