Catechol O-Methyltransferase Genetic Polymorphism in Panic Disorder
OBJECTIVE: The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients. METHOD: Fifty-one patients with panic disorder and 45 healthy...
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| Veröffentlicht in: | The American journal of psychiatry 2002-10, Vol.159 (10), p.1785-1787 |
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| container_title | The American journal of psychiatry |
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| creator | Woo, Jong-Min Yoon, Kyung-Sik Yu, Bum-Hee |
| description | OBJECTIVE: The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients. METHOD: Fifty-one patients with panic disorder and 45 healthy comparison subjects were tested for a genetic polymorphism of COMT. Clinical variables were assessed for the patients with panic disorder. RESULTS: The frequency of the L L genotype was significantly higher in the patients with panic disorder than in the healthy subjects (19.6% versus 2.2%). Panic disorder was significantly associated with the L allele and L L genotype. Patients with panic disorder who had the L L genotype showed poorer treatment response than those with other genotypes. CONCLUSIONS: These results suggest that the L L genotype of the COMT gene may be related to the development and treatment outcome of panic disorder in some patients. |
| doi_str_mv | 10.1176/appi.ajp.159.10.1785 |
| format | Article |
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METHOD: Fifty-one patients with panic disorder and 45 healthy comparison subjects were tested for a genetic polymorphism of COMT. Clinical variables were assessed for the patients with panic disorder. RESULTS: The frequency of the L L genotype was significantly higher in the patients with panic disorder than in the healthy subjects (19.6% versus 2.2%). Panic disorder was significantly associated with the L allele and L L genotype. Patients with panic disorder who had the L L genotype showed poorer treatment response than those with other genotypes. CONCLUSIONS: These results suggest that the L L genotype of the COMT gene may be related to the development and treatment outcome of panic disorder in some patients.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.159.10.1785</identifier><identifier>PMID: 12359690</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age of Onset ; Agoraphobia - diagnosis ; Agoraphobia - genetics ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Catechol O-Methyltransferase - genetics ; Female ; Gene Frequency - genetics ; Genetic Predisposition to Disease - genetics ; Genotype ; Humans ; Korea - epidemiology ; Male ; Medical sciences ; Panic disorder ; Panic Disorder - diagnosis ; Panic Disorder - epidemiology ; Panic Disorder - genetics ; Polymorphism, Genetic - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Treatment Outcome</subject><ispartof>The American journal of psychiatry, 2002-10, Vol.159 (10), p.1785-1787</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a441t-999b31e745fef319444cea20eaec876378250b92d9124ae1b4bfc2fb6cfd90453</citedby><cites>FETCH-LOGICAL-a441t-999b31e745fef319444cea20eaec876378250b92d9124ae1b4bfc2fb6cfd90453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.159.10.1785$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.159.10.1785$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2855,21626,21627,21628,27924,27925,77794,77799</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13959624$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12359690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woo, Jong-Min</creatorcontrib><creatorcontrib>Yoon, Kyung-Sik</creatorcontrib><creatorcontrib>Yu, Bum-Hee</creatorcontrib><title>Catechol O-Methyltransferase Genetic Polymorphism in Panic Disorder</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients. METHOD: Fifty-one patients with panic disorder and 45 healthy comparison subjects were tested for a genetic polymorphism of COMT. Clinical variables were assessed for the patients with panic disorder. RESULTS: The frequency of the L L genotype was significantly higher in the patients with panic disorder than in the healthy subjects (19.6% versus 2.2%). Panic disorder was significantly associated with the L allele and L L genotype. Patients with panic disorder who had the L L genotype showed poorer treatment response than those with other genotypes. CONCLUSIONS: These results suggest that the L L genotype of the COMT gene may be related to the development and treatment outcome of panic disorder in some patients.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age of Onset</subject><subject>Agoraphobia - diagnosis</subject><subject>Agoraphobia - genetics</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Korea - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Panic disorder</subject><subject>Panic Disorder - diagnosis</subject><subject>Panic Disorder - epidemiology</subject><subject>Panic Disorder - genetics</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Treatment Outcome</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gche9LY1n83mKFWrUGkPCt6WbDqhKftlsnvovzdtF7x5GubleWfgQeiW4Ckhcvao29ZN9a6dEqGmh1Bm4gyNiWAilZRm52iMMaapEux7hK5C2MUVM0kv0YhQJtRM4TGaz3UHZtuUySr9gG67Lzuv62DB6wDJAmronEnWTbmvGt9uXagSVydrXcf02YXGb8BfowurywA3w5ygr9eXz_lbulwt3udPy1RzTrpUKVUwApILC5YRxTk3oCkGDSaTMyYzKnCh6EYRyjWQghfWUFvMjN0ozAWboIfT3dY3Pz2ELq9cMFCWuoamD7mkhElODyA_gcY3IXiweetdpf0-Jzg_yMsP8vIoL4_yjmGUF2t3w_2-qGDzVxpsReB-AHQwurTRlHHhj2MqcpRHjpy445td0_s6evn_-S_6M4oC</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Woo, Jong-Min</creator><creator>Yoon, Kyung-Sik</creator><creator>Yu, Bum-Hee</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Catechol O-Methyltransferase Genetic Polymorphism in Panic Disorder</title><author>Woo, Jong-Min ; Yoon, Kyung-Sik ; Yu, Bum-Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a441t-999b31e745fef319444cea20eaec876378250b92d9124ae1b4bfc2fb6cfd90453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age of Onset</topic><topic>Agoraphobia - diagnosis</topic><topic>Agoraphobia - genetics</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Korea - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Panic disorder</topic><topic>Panic Disorder - diagnosis</topic><topic>Panic Disorder - epidemiology</topic><topic>Panic Disorder - genetics</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woo, Jong-Min</creatorcontrib><creatorcontrib>Yoon, Kyung-Sik</creatorcontrib><creatorcontrib>Yu, Bum-Hee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woo, Jong-Min</au><au>Yoon, Kyung-Sik</au><au>Yu, Bum-Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catechol O-Methyltransferase Genetic Polymorphism in Panic Disorder</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>159</volume><issue>10</issue><spage>1785</spage><epage>1787</epage><pages>1785-1787</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients. METHOD: Fifty-one patients with panic disorder and 45 healthy comparison subjects were tested for a genetic polymorphism of COMT. Clinical variables were assessed for the patients with panic disorder. RESULTS: The frequency of the L L genotype was significantly higher in the patients with panic disorder than in the healthy subjects (19.6% versus 2.2%). Panic disorder was significantly associated with the L allele and L L genotype. Patients with panic disorder who had the L L genotype showed poorer treatment response than those with other genotypes. CONCLUSIONS: These results suggest that the L L genotype of the COMT gene may be related to the development and treatment outcome of panic disorder in some patients.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>12359690</pmid><doi>10.1176/appi.ajp.159.10.1785</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Adult and adolescent clinical studies Age of Onset Agoraphobia - diagnosis Agoraphobia - genetics Anxiety disorders. Neuroses Biological and medical sciences Catechol O-Methyltransferase - genetics Female Gene Frequency - genetics Genetic Predisposition to Disease - genetics Genotype Humans Korea - epidemiology Male Medical sciences Panic disorder Panic Disorder - diagnosis Panic Disorder - epidemiology Panic Disorder - genetics Polymorphism, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Treatment Outcome |
| title | Catechol O-Methyltransferase Genetic Polymorphism in Panic Disorder |
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