Autoantibodies to inner ear and endothelial antigens in Cogan's syndrome

Cogan's syndrome is a chronic inflammatory disease of unknown origin, characterised by sensorineural hearing loss, episcleritis, and vasculitis. An autoimmune origin has been suggested but not proven. Our aim was to establish whether or not an autoimmune process is the cause of the disease. We...

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Veröffentlicht in:	The Lancet (British edition) 2002-09, Vol.360 (9337), p.915-921
Hauptverfasser:	Lunardi, Claudio, Bason, Caterina, Leandri, Massimo, Navone, Riccardo, Lestani, Maurizio, Millo, Enrico, Benatti, Umberto, Cilli, Michele, Beri, Ruggero, Corrocher, Roberto, Puccetti, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal diseases Animals Antibodies Antigens Autoantibodies Autoantibodies - classification Autoantibodies - isolation & purification Autoantigens Autoimmune diseases Autoimmune Diseases - genetics Autoimmune Diseases - immunology Binding sites Biological and medical sciences Case-Control Studies Cell density Cell proliferation Cell surface Cells, Cultured Cloning Cochlea Connexin 26 Core protein Deafness Ear Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ears & hearing Endothelial cells Enzyme-Linked Immunosorbent Assay Eye Eye diseases Female Hearing loss Hearing Loss, Sensorineural - genetics Hearing Loss, Sensorineural - immunology Humans Immune system Immunization Immunoglobulin G Immunoglobulins Infections Inner ear Medical disorders Medical sciences Mice Mice, Inbred C57BL Molecular chains Molecular Mimicry Mutation Non tumoral diseases Otorhinolaryngology. Stomatology Pathogenesis Patients Peptide Library Peptides Phosphatase Protein Phosphatase 1 Protein Tyrosine Phosphatases - immunology Protein-tyrosine-phosphatase Proteins Receptor-Like Protein Tyrosine Phosphatases, Class 3 Similarity Syndrome Tyrosine Vasculitis
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