cGMP-dependent Protein Kinase Inhibits Serum-response Element-dependent Transcription by Inhibiting Rho Activation and Functions

RhoA, in its active GTP-bound form, stimulates transcription through activation of the serum-response factor (SRF). We found that cGMP inhibited serum-induced Rho·GTP loading and transcriptional activation of SRF-dependent reporter genes in smooth muscle and glial cells in a cGMP-dependent protein k...

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Veröffentlicht in:	The Journal of biological chemistry 2002-10, Vol.277 (40), p.37382-37393
Hauptverfasser:	Gudi, Tanima, Chen, Jeffrey C., Casteel, Darren E., Seasholtz, Tammy M., Boss, Gerry R., Pilz, Renate B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cattle Coleoptera Cyclic GMP - pharmacology Cyclic GMP-Dependent Protein Kinase Type I Cyclic GMP-Dependent Protein Kinases - genetics Cyclic GMP-Dependent Protein Kinases - metabolism DNA Primers DNA, Complementary Enzyme Activation - drug effects Gene Expression Regulation Genes, Reporter Genetic Vectors Heart - physiology Humans Luciferases - genetics Pulmonary Artery - physiology Recombinant Fusion Proteins - metabolism rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - physiology Serum Response Element - physiology Transcription, Genetic - physiology Vinculin - genetics
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