Induction of macrophage inflammatory protein-1 beta gene expression in human monocytes by lipopolysaccharide and IL-7
HuMIP-1 beta is a member of a gene family of inflammatory cytokines whose expression is induced by proinflammatory and mitogenic stimuli. The gene was rapidly induced in human peripheral blood monocytes by either LPS or IL-7. However, IL-7 was unable to induce HuMIP-1 beta mRNA in peripheral blood T...
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| Veröffentlicht in: | The Journal of immunology (1950) 1991-10, Vol.147 (7), p.2234-2239 |
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| container_title | The Journal of immunology (1950) |
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| creator | Ziegler, SF Tough, TW Franklin, TL Armitage, RJ Alderson, MR |
| description | HuMIP-1 beta is a member of a gene family of inflammatory cytokines whose expression is induced by proinflammatory and mitogenic stimuli. The gene was rapidly induced in human peripheral blood monocytes by either LPS or IL-7. However, IL-7 was unable to induce HuMIP-1 beta mRNA in peripheral blood T cells. The induction of HuMIP-1 beta mRNA in monocytes by IL-7 or LPS was inhibited by IL-4. The 5'-regulatory region of the HuMIP-1 beta gene was cloned and sequenced. An analysis of this sequence revealed three consensus-binding sites for the nuclear factor PU.1 and three potential glucocorticoid response elements. However, the HuMIP-1 beta gene appears to be unresponsive to dexamethasone. Also present in the 5'-regulatory region was a LPS-responsive element located within 455 bp 5' to the start of transcription. |
| doi_str_mv | 10.4049/jimmunol.147.7.2234 |
| format | Article |
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The gene was rapidly induced in human peripheral blood monocytes by either LPS or IL-7. However, IL-7 was unable to induce HuMIP-1 beta mRNA in peripheral blood T cells. The induction of HuMIP-1 beta mRNA in monocytes by IL-7 or LPS was inhibited by IL-4. The 5'-regulatory region of the HuMIP-1 beta gene was cloned and sequenced. An analysis of this sequence revealed three consensus-binding sites for the nuclear factor PU.1 and three potential glucocorticoid response elements. However, the HuMIP-1 beta gene appears to be unresponsive to dexamethasone. Also present in the 5'-regulatory region was a LPS-responsive element located within 455 bp 5' to the start of transcription.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.147.7.2234</identifier><identifier>PMID: 1918960</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Base Sequence ; Chemokine CCL4 ; Cytokines - genetics ; Gene Expression Regulation - drug effects ; Genes, Regulator ; Humans ; Interleukin-4 - pharmacology ; Interleukin-7 - pharmacology ; Lipopolysaccharides ; Macrophage Inflammatory Proteins ; Molecular Sequence Data ; Monocytes - drug effects ; Monocytes - metabolism ; Monokines - genetics ; Receptors, Immunologic - analysis ; Receptors, Interleukin-7 ; RNA, Messenger - analysis</subject><ispartof>The Journal of immunology (1950), 1991-10, Vol.147 (7), p.2234-2239</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-5ebdaeadf6ee3c71241252c8f25fe12cc1f88146e6a407e06ce09b4c06f0fd8f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1918960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ziegler, SF</creatorcontrib><creatorcontrib>Tough, TW</creatorcontrib><creatorcontrib>Franklin, TL</creatorcontrib><creatorcontrib>Armitage, RJ</creatorcontrib><creatorcontrib>Alderson, MR</creatorcontrib><title>Induction of macrophage inflammatory protein-1 beta gene expression in human monocytes by lipopolysaccharide and IL-7</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>HuMIP-1 beta is a member of a gene family of inflammatory cytokines whose expression is induced by proinflammatory and mitogenic stimuli. The gene was rapidly induced in human peripheral blood monocytes by either LPS or IL-7. However, IL-7 was unable to induce HuMIP-1 beta mRNA in peripheral blood T cells. The induction of HuMIP-1 beta mRNA in monocytes by IL-7 or LPS was inhibited by IL-4. The 5'-regulatory region of the HuMIP-1 beta gene was cloned and sequenced. An analysis of this sequence revealed three consensus-binding sites for the nuclear factor PU.1 and three potential glucocorticoid response elements. However, the HuMIP-1 beta gene appears to be unresponsive to dexamethasone. Also present in the 5'-regulatory region was a LPS-responsive element located within 455 bp 5' to the start of transcription.</description><subject>Base Sequence</subject><subject>Chemokine CCL4</subject><subject>Cytokines - genetics</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes, Regulator</subject><subject>Humans</subject><subject>Interleukin-4 - pharmacology</subject><subject>Interleukin-7 - pharmacology</subject><subject>Lipopolysaccharides</subject><subject>Macrophage Inflammatory Proteins</subject><subject>Molecular Sequence Data</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - metabolism</subject><subject>Monokines - genetics</subject><subject>Receptors, Immunologic - analysis</subject><subject>Receptors, Interleukin-7</subject><subject>RNA, Messenger - analysis</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvCL0BIPsEpi-04dnJEVaErrcQFzpbjjDeu_BHsREv-PVltEdw4zWGe95VmHoTeUbLnhHefnlwIS0x-T7ncyz1jNX-BdrRpSCUEES_RjhDGKiqFfI1uS3kihAjC-A26oR1tO0F2aDnEYTGzSxEni4M2OU2jPgF20Xodgp5TXvGU0wwuVhT3MGt8gggYfk0ZSrkkXcTjEnTEIcVk1hkK7lfs3ZSm5NeijRl1dgNgHQd8OFbyDXpltS_w9nneoR9fHr7fP1bHb18P95-PleGSz1UD_aBBD1YA1EZSxilrmGktayxQZgy1bUu5AKE5kUCEAdL13BBhiR1aW9-hD9fe7YCfC5RZBVcMeK8jpKUoyWgteFP_F6SCUNk1cgPrK7g9qpQMVk3ZBZ1XRYm6WFF_rKjNipLqYmVLvX-uX_oAw9_MVcO2_3jdj-40nl0GVYL2fqOpOp_P_zT9Br0Jmto</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>Ziegler, SF</creator><creator>Tough, TW</creator><creator>Franklin, TL</creator><creator>Armitage, RJ</creator><creator>Alderson, MR</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19911001</creationdate><title>Induction of macrophage inflammatory protein-1 beta gene expression in human monocytes by lipopolysaccharide and IL-7</title><author>Ziegler, SF ; Tough, TW ; Franklin, TL ; Armitage, RJ ; Alderson, MR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-5ebdaeadf6ee3c71241252c8f25fe12cc1f88146e6a407e06ce09b4c06f0fd8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Base Sequence</topic><topic>Chemokine CCL4</topic><topic>Cytokines - genetics</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genes, Regulator</topic><topic>Humans</topic><topic>Interleukin-4 - pharmacology</topic><topic>Interleukin-7 - pharmacology</topic><topic>Lipopolysaccharides</topic><topic>Macrophage Inflammatory Proteins</topic><topic>Molecular Sequence Data</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - metabolism</topic><topic>Monokines - genetics</topic><topic>Receptors, Immunologic - analysis</topic><topic>Receptors, Interleukin-7</topic><topic>RNA, Messenger - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ziegler, SF</creatorcontrib><creatorcontrib>Tough, TW</creatorcontrib><creatorcontrib>Franklin, TL</creatorcontrib><creatorcontrib>Armitage, RJ</creatorcontrib><creatorcontrib>Alderson, MR</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ziegler, SF</au><au>Tough, TW</au><au>Franklin, TL</au><au>Armitage, RJ</au><au>Alderson, MR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of macrophage inflammatory protein-1 beta gene expression in human monocytes by lipopolysaccharide and IL-7</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>147</volume><issue>7</issue><spage>2234</spage><epage>2239</epage><pages>2234-2239</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>HuMIP-1 beta is a member of a gene family of inflammatory cytokines whose expression is induced by proinflammatory and mitogenic stimuli. 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| ispartof | The Journal of immunology (1950), 1991-10, Vol.147 (7), p.2234-2239 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Base Sequence Chemokine CCL4 Cytokines - genetics Gene Expression Regulation - drug effects Genes, Regulator Humans Interleukin-4 - pharmacology Interleukin-7 - pharmacology Lipopolysaccharides Macrophage Inflammatory Proteins Molecular Sequence Data Monocytes - drug effects Monocytes - metabolism Monokines - genetics Receptors, Immunologic - analysis Receptors, Interleukin-7 RNA, Messenger - analysis |
| title | Induction of macrophage inflammatory protein-1 beta gene expression in human monocytes by lipopolysaccharide and IL-7 |
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