Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream
Computerized image analysis of silicone replicas, a reproducible, objective technique for measuring skin topography, was used in addition to clinical measures in two multicenter, double-blind, randomized, controlled studies of tretinoin emollient cream, a new formulation for treating photodamaged sk...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1991-08, Vol.25 (2), p.231-237 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Grove, Gary L. Grove, Mary Jo Leyden, James J. Lufrano, Laura Schwab, Barry Perry, Barbara H. Thorne, E. George |
| description | Computerized image analysis of silicone replicas, a reproducible, objective technique for measuring skin topography, was used in addition to clinical measures in two multicenter, double-blind, randomized, controlled studies of tretinoin emollient cream, a new formulation for treating photodamaged skin. Previously, the skin replica technique had been successfully used in a pilot study of tretinoin 0.05% cream by one investigator. In the present studies, subjects treated for 24 weeks with tretinoin emollient 0.05% cream consistently showed more improvement in skin topography than did vehicle-treated patients. A 0.01% concentration of tretinoin emollient cream also improved skin topography to a greater extent than the vehicle, while the lowest concentration tested (0.001%) showed little difference from vehicle. These results, reflecting a smoothening of the skin surface in tretinoin emollient cream-treated subjects; were consistent with clinical data showing greater improvement in fine wrinkling and roughness after tretinoin emollient cream therapy than after vehicle therapy. Findings from these multicenter studies confirm the value of the skin replica technique and help establish the efficacy of tretinoin emollient 0.05% cream for photodamaged skin. |
| doi_str_mv | 10.1016/0190-9622(91)70187-7 |
| format | Article |
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A 0.01% concentration of tretinoin emollient cream also improved skin topography to a greater extent than the vehicle, while the lowest concentration tested (0.001%) showed little difference from vehicle. These results, reflecting a smoothening of the skin surface in tretinoin emollient cream-treated subjects; were consistent with clinical data showing greater improvement in fine wrinkling and roughness after tretinoin emollient cream therapy than after vehicle therapy. Findings from these multicenter studies confirm the value of the skin replica technique and help establish the efficacy of tretinoin emollient 0.05% cream for photodamaged skin.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/0190-9622(91)70187-7</identifier><identifier>PMID: 1918458</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Double-Blind Method ; Emollients ; Female ; Humans ; Image Interpretation, Computer-Assisted - methods ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Replica Techniques ; Skin Aging - drug effects ; Skin, nail, hair, dermoskeleton ; Tretinoin - therapeutic use</subject><ispartof>Journal of the American Academy of Dermatology, 1991-08, Vol.25 (2), p.231-237</ispartof><rights>1991 American Academy of Dermatology, Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-7a32401350d88c4f07132b96ab9621b4172750539d5d990ae704617d98dfe2943</citedby><cites>FETCH-LOGICAL-c386t-7a32401350d88c4f07132b96ab9621b4172750539d5d990ae704617d98dfe2943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0190-9622(91)70187-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5600200$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1918458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grove, Gary L.</creatorcontrib><creatorcontrib>Grove, Mary Jo</creatorcontrib><creatorcontrib>Leyden, James J.</creatorcontrib><creatorcontrib>Lufrano, Laura</creatorcontrib><creatorcontrib>Schwab, Barry</creatorcontrib><creatorcontrib>Perry, Barbara H.</creatorcontrib><creatorcontrib>Thorne, E. George</creatorcontrib><title>Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Computerized image analysis of silicone replicas, a reproducible, objective technique for measuring skin topography, was used in addition to clinical measures in two multicenter, double-blind, randomized, controlled studies of tretinoin emollient cream, a new formulation for treating photodamaged skin. Previously, the skin replica technique had been successfully used in a pilot study of tretinoin 0.05% cream by one investigator. In the present studies, subjects treated for 24 weeks with tretinoin emollient 0.05% cream consistently showed more improvement in skin topography than did vehicle-treated patients. A 0.01% concentration of tretinoin emollient cream also improved skin topography to a greater extent than the vehicle, while the lowest concentration tested (0.001%) showed little difference from vehicle. These results, reflecting a smoothening of the skin surface in tretinoin emollient cream-treated subjects; were consistent with clinical data showing greater improvement in fine wrinkling and roughness after tretinoin emollient cream therapy than after vehicle therapy. Findings from these multicenter studies confirm the value of the skin replica technique and help establish the efficacy of tretinoin emollient 0.05% cream for photodamaged skin.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Emollients</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Replica Techniques</subject><subject>Skin Aging - drug effects</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Tretinoin - therapeutic use</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRyENFDa1X6I8llQRa_YMGDiseQSaqdaHenTTLK_HszzrDePBR1eJ8qqh7GHiO8RMDhFaCGRg9CPNf4QgIq2cg7bIOgZTNIJe-yzS1ynz3I-TsA6K6VF-wCNaquVxv29dOPsPBE6xSc5Xax0yGHzOPI110s0dvZfiPP85GyY6HEy46SXQ_8dyg7XhKVsMQa0hynKdBSuEtk54fs3minTI_O_ZJ9efvm8_X75ubjuw_Xr28a16qhNNK2ogNse_BKuW4Eia3Y6sHWErjtUArZQ99q33utwZKEbkDptfIjifrMJXt22rum-HNPuZg5ZEfTZBeK-2ykwLZTUlWwO4EuxZwTjWZNYbbpYBDM0ac5yjJHWUaj-evTyDr25Lx_v53J_xs6Caz503Nus7PTmOziQr7F-gFAAFTs6oRRdfErUDLZVVmOfEjkivEx_P-OPz3rkG8</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>Grove, Gary L.</creator><creator>Grove, Mary Jo</creator><creator>Leyden, James J.</creator><creator>Lufrano, Laura</creator><creator>Schwab, Barry</creator><creator>Perry, Barbara H.</creator><creator>Thorne, E. 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George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-7a32401350d88c4f07132b96ab9621b4172750539d5d990ae704617d98dfe2943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Emollients</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Replica Techniques</topic><topic>Skin Aging - drug effects</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Tretinoin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grove, Gary L.</creatorcontrib><creatorcontrib>Grove, Mary Jo</creatorcontrib><creatorcontrib>Leyden, James J.</creatorcontrib><creatorcontrib>Lufrano, Laura</creatorcontrib><creatorcontrib>Schwab, Barry</creatorcontrib><creatorcontrib>Perry, Barbara H.</creatorcontrib><creatorcontrib>Thorne, E. 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George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1991-08-01</date><risdate>1991</risdate><volume>25</volume><issue>2</issue><spage>231</spage><epage>237</epage><pages>231-237</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Computerized image analysis of silicone replicas, a reproducible, objective technique for measuring skin topography, was used in addition to clinical measures in two multicenter, double-blind, randomized, controlled studies of tretinoin emollient cream, a new formulation for treating photodamaged skin. Previously, the skin replica technique had been successfully used in a pilot study of tretinoin 0.05% cream by one investigator. In the present studies, subjects treated for 24 weeks with tretinoin emollient 0.05% cream consistently showed more improvement in skin topography than did vehicle-treated patients. A 0.01% concentration of tretinoin emollient cream also improved skin topography to a greater extent than the vehicle, while the lowest concentration tested (0.001%) showed little difference from vehicle. These results, reflecting a smoothening of the skin surface in tretinoin emollient cream-treated subjects; were consistent with clinical data showing greater improvement in fine wrinkling and roughness after tretinoin emollient cream therapy than after vehicle therapy. Findings from these multicenter studies confirm the value of the skin replica technique and help establish the efficacy of tretinoin emollient 0.05% cream for photodamaged skin.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>1918458</pmid><doi>10.1016/0190-9622(91)70187-7</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 1991-08, Vol.25 (2), p.231-237 |
| issn | 0190-9622 1097-6787 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Biological and medical sciences Dose-Response Relationship, Drug Double-Blind Method Emollients Female Humans Image Interpretation, Computer-Assisted - methods Male Medical sciences Middle Aged Pharmacology. Drug treatments Replica Techniques Skin Aging - drug effects Skin, nail, hair, dermoskeleton Tretinoin - therapeutic use |
| title | Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream |
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