Polymorphisms of the Cytomegalovirus (CMV)–Encoded Tumor Necrosis Factor–α and β-Chemokine Receptors in Congenital CMV Disease
Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)–α–like receptor gene, the US28 β-chemokine receptor gene,...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-10, Vol.186 (8), p.1057-1064 |
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| container_title | The Journal of infectious diseases |
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| creator | Arav-Boger, Ravit Willoughby, Rodney E. Pass, Robert F. Zong, Jian-Chao Jang, Won-Jong Alcendor, Donald Hayward, Gary S. |
| description | Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)–α–like receptor gene, the US28 β-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P=.04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P=.864 and P=.765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-α–like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome–associated CMV diseases |
| doi_str_mv | 10.1086/344238 |
| format | Article |
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To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)–α–like receptor gene, the US28 β-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P=.04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P=.864 and P=.765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-α–like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome–associated CMV diseases</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/344238</identifier><identifier>PMID: 12355354</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Amino Acid Sequence ; Autopsies ; Biological and medical sciences ; Cytomegalovirus ; Cytomegalovirus - genetics ; Cytomegalovirus - pathogenicity ; Cytomegalovirus infections ; Cytomegalovirus Infections - congenital ; Cytomegalovirus Infections - mortality ; Cytomegalovirus Infections - transmission ; Cytomegalovirus Infections - virology ; DNA ; Female ; Fetus ; Genes, Viral - genetics ; Genotype ; Genotypes ; Human viral diseases ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases - mortality ; Infant, Newborn, Diseases - virology ; Infants ; Infections ; Infectious Disease Transmission, Vertical ; Infectious diseases ; Major Articles ; Medical sciences ; Membrane Glycoproteins - chemistry ; Membrane Glycoproteins - genetics ; Miscellaneous ; Molecular Sequence Data ; Phylogeny ; Polymerase Chain Reaction ; Polymorphism, Genetic - genetics ; Pregnancy ; Receptors, Chemokine - chemistry ; Receptors, Chemokine - genetics ; Receptors, Tumor Necrosis Factor - chemistry ; Receptors, Tumor Necrosis Factor - genetics ; Tissue samples ; Viral diseases ; Viral Proteins - chemistry ; Viral Proteins - genetics ; Virulence</subject><ispartof>The Journal of infectious diseases, 2002-10, Vol.186 (8), p.1057-1064</ispartof><rights>Copyright 2002 Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8850c9b7bb85702e267c61d6731ba2061d8b8a13ef4f8e5a253561b15d7756073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30085203$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30085203$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13982879$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12355354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arav-Boger, Ravit</creatorcontrib><creatorcontrib>Willoughby, Rodney E.</creatorcontrib><creatorcontrib>Pass, Robert F.</creatorcontrib><creatorcontrib>Zong, Jian-Chao</creatorcontrib><creatorcontrib>Jang, Won-Jong</creatorcontrib><creatorcontrib>Alcendor, Donald</creatorcontrib><creatorcontrib>Hayward, Gary S.</creatorcontrib><title>Polymorphisms of the Cytomegalovirus (CMV)–Encoded Tumor Necrosis Factor–α and β-Chemokine Receptors in Congenital CMV Disease</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)–α–like receptor gene, the US28 β-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P=.04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P=.864 and P=.765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-α–like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome–associated CMV diseases</description><subject>Amino Acid Sequence</subject><subject>Autopsies</subject><subject>Biological and medical sciences</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - genetics</subject><subject>Cytomegalovirus - pathogenicity</subject><subject>Cytomegalovirus infections</subject><subject>Cytomegalovirus Infections - congenital</subject><subject>Cytomegalovirus Infections - mortality</subject><subject>Cytomegalovirus Infections - transmission</subject><subject>Cytomegalovirus Infections - virology</subject><subject>DNA</subject><subject>Female</subject><subject>Fetus</subject><subject>Genes, Viral - genetics</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases - mortality</subject><subject>Infant, Newborn, Diseases - virology</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Infectious diseases</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - chemistry</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Pregnancy</subject><subject>Receptors, Chemokine - chemistry</subject><subject>Receptors, Chemokine - genetics</subject><subject>Receptors, Tumor Necrosis Factor - chemistry</subject><subject>Receptors, Tumor Necrosis Factor - genetics</subject><subject>Tissue samples</subject><subject>Viral diseases</subject><subject>Viral Proteins - chemistry</subject><subject>Viral Proteins - genetics</subject><subject>Virulence</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokOBNwC5CxAsAv6JY2eJ0g4Fyl8pFWJjOc5Nx20ShzhBzI4Fb8CTwIP0IXgSPJpRZ4VY2dL5fO71OQjdpeQJJSp7ytOUcXUNzajgMskyyq-jGSGMJVTl-Q66FcI5ISTlmbyJdijjQnCRztCPd75Ztn7oFy60AfsajwvAxXL0LZyZxn91wxTwo-L16eM_338edNZXUOGTKT7Bb8AOPriA58aOfoj65S9sugpf_k6KBbT-wnWAj8FCH-WAXYcL351B50bT4GiJ910AE-A2ulGbJsCdzbmLPs4PTorD5Ojt8xfFs6PEpoyNiVKC2LyUZamEJAxYJm1Gq0xyWhpG4lWVylAOdVorEIbFL2a0pKKSUmRE8l30cO3bD_7LBGHUrQsWmsZ04KegJaOc5zT_L0iVpHEg34KrJMIAte4H15phqSnRq2L0upgI3t84TmUL1RbbNBGBBxvABGuaejCddWHL8VwxJVer7a05P_X_HnZvzZyHGPwVxQlRgpHV1slad2GEb1e6GS50DFMKffjpsz7efz__8OrlqS74X7Nauio</recordid><startdate>20021015</startdate><enddate>20021015</enddate><creator>Arav-Boger, Ravit</creator><creator>Willoughby, Rodney E.</creator><creator>Pass, Robert F.</creator><creator>Zong, Jian-Chao</creator><creator>Jang, Won-Jong</creator><creator>Alcendor, Donald</creator><creator>Hayward, Gary S.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20021015</creationdate><title>Polymorphisms of the Cytomegalovirus (CMV)–Encoded Tumor Necrosis Factor–α and β-Chemokine Receptors in Congenital CMV Disease</title><author>Arav-Boger, Ravit ; 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To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)–α–like receptor gene, the US28 β-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P=.04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P=.864 and P=.765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-α–like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome–associated CMV diseases</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12355354</pmid><doi>10.1086/344238</doi><tpages>8</tpages></addata></record> |
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| subjects | Amino Acid Sequence Autopsies Biological and medical sciences Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus - pathogenicity Cytomegalovirus infections Cytomegalovirus Infections - congenital Cytomegalovirus Infections - mortality Cytomegalovirus Infections - transmission Cytomegalovirus Infections - virology DNA Female Fetus Genes, Viral - genetics Genotype Genotypes Human viral diseases Humans Infant, Newborn Infant, Newborn, Diseases - mortality Infant, Newborn, Diseases - virology Infants Infections Infectious Disease Transmission, Vertical Infectious diseases Major Articles Medical sciences Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Miscellaneous Molecular Sequence Data Phylogeny Polymerase Chain Reaction Polymorphism, Genetic - genetics Pregnancy Receptors, Chemokine - chemistry Receptors, Chemokine - genetics Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor - genetics Tissue samples Viral diseases Viral Proteins - chemistry Viral Proteins - genetics Virulence |
| title | Polymorphisms of the Cytomegalovirus (CMV)–Encoded Tumor Necrosis Factor–α and β-Chemokine Receptors in Congenital CMV Disease |
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