The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis
The fork head domain-containing gene family ( Fox) comprises over 20 members in mammals and is defined by a conserved 110 amino-acid motif containing a winged helix structure DNA-binding domain. The members of this gene family have been implicated as key regulators of embryogenesis, cell cycling, ce...
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| Veröffentlicht in: | Mechanisms of development 2002-10, Vol.118 (1), p.161-163 |
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| creator | Tribioli, Carla Robledo, Raymond F Lufkin, Thomas |
| description | The fork head domain-containing gene family (
Fox) comprises over 20 members in mammals and is defined by a conserved 110 amino-acid motif containing a winged helix structure DNA-binding domain. The members of this gene family have been implicated as key regulators of embryogenesis, cell cycling, cell lineage restriction and cancer. The
Foxn2 gene (
Ches1) is expressed in postgastrulation embryos in multiple tissues that serve as important signaling centers as well as end-stage-differentiated cell types that arise from different germ layers of the developing embryo. The dynamic and specific expression of
Foxn2 during embryonic development suggest multiple independent roles for
Foxn2 function during gestation. |
| doi_str_mv | 10.1016/S0925-4773(02)00220-4 |
| format | Article |
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Fox) comprises over 20 members in mammals and is defined by a conserved 110 amino-acid motif containing a winged helix structure DNA-binding domain. The members of this gene family have been implicated as key regulators of embryogenesis, cell cycling, cell lineage restriction and cancer. The
Foxn2 gene (
Ches1) is expressed in postgastrulation embryos in multiple tissues that serve as important signaling centers as well as end-stage-differentiated cell types that arise from different germ layers of the developing embryo. The dynamic and specific expression of
Foxn2 during embryonic development suggest multiple independent roles for
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Fox) comprises over 20 members in mammals and is defined by a conserved 110 amino-acid motif containing a winged helix structure DNA-binding domain. The members of this gene family have been implicated as key regulators of embryogenesis, cell cycling, cell lineage restriction and cancer. The
Foxn2 gene (
Ches1) is expressed in postgastrulation embryos in multiple tissues that serve as important signaling centers as well as end-stage-differentiated cell types that arise from different germ layers of the developing embryo. The dynamic and specific expression of
Foxn2 during embryonic development suggest multiple independent roles for
Foxn2 function during gestation.</description><subject>Amino Acid Motifs</subject><subject>Animals</subject><subject>Apical ectodermal ridge</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Central Nervous System - embryology</subject><subject>Craniofacial</subject><subject>DNA - metabolism</subject><subject>DNA, Complementary - metabolism</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Embryo</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Expressed Sequence Tags</subject><subject>Fork head</subject><subject>Forkhead Transcription Factors</subject><subject>Fox</subject><subject>Gastrula - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Growth factor</subject><subject>Homeobox gene</subject><subject>In Situ Hybridization</subject><subject>Limb</subject><subject>Mice</subject><subject>Nasopharynx</subject><subject>Nervous system</subject><subject>Olfactory</subject><subject>Protein Binding</subject><subject>RNA - metabolism</subject><subject>Signal Transduction</subject><subject>Somite</subject><subject>Time Factors</subject><subject>Winged helix</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BCUnUbCaj7ZpTyKLq4LoQT2HNJlqtG3WTFf039u6ix49DQPPvDPzELLP2SlnPD97YKXIklQpecTEMWNCsCRdIxNeKJHkMsvXyeQX2SLbiK-MMc5zvkm2uJAZ5wWbkPnjC9B2EX0HtA7xjb6AcfQZhnYWPjtBPVL4nEdABEd9R200nQ-1sd40J7TxbXVCp3cP1HSOYmh97y3tPeICkLox95lCW8WvMGaix12yUZsGYW9Vd8jT7PJxep3c3l_dTC9uEytz3ie8BCmrUg4317bgtayUq2VZ5AoYcCmdZEXqRKmMlJyldV4JowqVAZSFMFUud8jhMncew_twTK9bjxaaxnQQFqiVGFKKMh3AbAnaGBAj1HoefWvil-ZMj6r1j2o9etRM6B_Vepw7WC1YVC24v6mV2wE4XwIwvPnhIWq0HjoLzkewvXbB_7PiG5ycjXY</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Tribioli, Carla</creator><creator>Robledo, Raymond F</creator><creator>Lufkin, Thomas</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis</title><author>Tribioli, Carla ; 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Foxn2 gene (
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Foxn2 during embryonic development suggest multiple independent roles for
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amino Acid Motifs Animals Apical ectodermal ridge Cell Differentiation Cell Lineage Central Nervous System - embryology Craniofacial DNA - metabolism DNA, Complementary - metabolism DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Embryo Embryo, Mammalian - metabolism Expressed Sequence Tags Fork head Forkhead Transcription Factors Fox Gastrula - metabolism Gene Expression Regulation, Developmental Growth factor Homeobox gene In Situ Hybridization Limb Mice Nasopharynx Nervous system Olfactory Protein Binding RNA - metabolism Signal Transduction Somite Time Factors Winged helix |
| title | The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis |
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