Designing heterodimeric two-stranded alpha-helical coiled-coils. Effects of hydrophobicity and alpha-helical propensity on protein folding, stability, and specificity

The E/K coil, a heterodimeric coiled-coil, has been designed as a universal peptide capture and delivery system for use in applications such as biosensors and as an expression and affinity purification tag. In this design, heterodimer formation is specified through the placement of charged residues...

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Veröffentlicht in:	The Journal of biological chemistry 2002-10, Vol.277 (40), p.37272-37279
Hauptverfasser:	Litowski, Jennifer R, Hodges, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Chromatography, High Pressure Liquid Circular Dichroism Dimerization Drug Stability Helix-Turn-Helix Motifs Indicators and Reagents Models, Molecular Molecular Sequence Data Peptides - chemical synthesis Peptides - chemistry Protein Folding Protein Structure, Secondary
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