Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains
Despite its initial identification in neurons exposed to the seizure-inducing drug pentylentetrazole (PTZ), the function of the seizure-related gene SEZ-6 remains obscure. Expression analysis indicates specific expression in the adult brain and testis, and the structure of the predicted protein sugg...
Gespeichert in:
| Veröffentlicht in: | Mechanisms of development 2002-10, Vol.118 (1), p.171-174 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 174 |
|---|---|
| container_issue | 1 |
| container_start_page | 171 |
| container_title | Mechanisms of development |
| container_volume | 118 |
| creator | Kim, Mary H. Gunnersen, Jenny M. Tan, Seong-Seng |
| description | Despite its initial identification in neurons exposed to the seizure-inducing drug pentylentetrazole (PTZ), the function of the seizure-related gene
SEZ-6 remains obscure. Expression analysis indicates specific expression in the adult brain and testis, and the structure of the predicted protein suggests putative roles in cell–cell recognition and signalling. We report here that type I
SEZ-6 mRNA is strongly expressed in highly specific regions in the developing forebrain. Specifically, the pattern of
SEZ-6 expression is closely tied with the emergence of the neocortical layers and hippocampus, and implies a forebrain-specific role for this gene during development. In the adult hippocampus,
SEZ-6 appears to be a CA1-specific regional marker. |
| doi_str_mv | 10.1016/S0925-4773(02)00238-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72133091</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0925477302002381</els_id><sourcerecordid>72133091</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-e7498344986265191228cfa2a760b01857f0859e393d64a6adeb863643a076ce3</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EgvLxE0CeEAwBn53YyYRQxZdUiQEYYLFc-wJGaVzsBAG_npRWMLLcLc97r-4hZB_YCTCQp3es4kWWKyWOGD9mjIsygzUyglLxTIpCrpPRL7JFtlN6ZYwBSNgkW8BFAVDyEXmcBGsa_4WO4sc8Yko-tDTUtHtBmtB_9RGziI3pBuIZW6R3F0-ZpL6lDt-xCXPfPlPTOmpc33S0DhGn0fg27ZKN2jQJ91Z7hzxcXtyPr7PJ7dXN-HyS2ZyrLkOVV6XIhyG5LKACzktbG26UZFMGZaFqVhYViko4mRtpHE5LKWQuDFPSotghh8u78xjeekydnvlksWlMi6FPWnEQglUwgMUStDGkFLHW8-hnJn5qYHrhVP841QthmnH941Qvcgergn46Q_eXWkkcgLMlgMOb7x6jTtZja9H5iLbTLvh_Kr4BT4iE7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72133091</pqid></control><display><type>article</type><title>Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Kim, Mary H. ; Gunnersen, Jenny M. ; Tan, Seong-Seng</creator><creatorcontrib>Kim, Mary H. ; Gunnersen, Jenny M. ; Tan, Seong-Seng</creatorcontrib><description>Despite its initial identification in neurons exposed to the seizure-inducing drug pentylentetrazole (PTZ), the function of the seizure-related gene
SEZ-6 remains obscure. Expression analysis indicates specific expression in the adult brain and testis, and the structure of the predicted protein suggests putative roles in cell–cell recognition and signalling. We report here that type I
SEZ-6 mRNA is strongly expressed in highly specific regions in the developing forebrain. Specifically, the pattern of
SEZ-6 expression is closely tied with the emergence of the neocortical layers and hippocampus, and implies a forebrain-specific role for this gene during development. In the adult hippocampus,
SEZ-6 appears to be a CA1-specific regional marker.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/S0925-4773(02)00238-1</identifier><identifier>PMID: 12351182</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Blotting, Northern ; Brain - embryology ; Hippocampus - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neocortex ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - genetics ; Prosencephalon - embryology ; Protein Isoforms ; RNA, Messenger - metabolism ; Seizure related ; Seizures ; Serial analysis of gene expression ; SEZ-6 ; Signal Transduction ; Testis - embryology ; Thalamic eminence ; Time Factors</subject><ispartof>Mechanisms of development, 2002-10, Vol.118 (1), p.171-174</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-e7498344986265191228cfa2a760b01857f0859e393d64a6adeb863643a076ce3</citedby><cites>FETCH-LOGICAL-c427t-e7498344986265191228cfa2a760b01857f0859e393d64a6adeb863643a076ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0925-4773(02)00238-1$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12351182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Mary H.</creatorcontrib><creatorcontrib>Gunnersen, Jenny M.</creatorcontrib><creatorcontrib>Tan, Seong-Seng</creatorcontrib><title>Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>Despite its initial identification in neurons exposed to the seizure-inducing drug pentylentetrazole (PTZ), the function of the seizure-related gene
SEZ-6 remains obscure. Expression analysis indicates specific expression in the adult brain and testis, and the structure of the predicted protein suggests putative roles in cell–cell recognition and signalling. We report here that type I
SEZ-6 mRNA is strongly expressed in highly specific regions in the developing forebrain. Specifically, the pattern of
SEZ-6 expression is closely tied with the emergence of the neocortical layers and hippocampus, and implies a forebrain-specific role for this gene during development. In the adult hippocampus,
SEZ-6 appears to be a CA1-specific regional marker.</description><subject>Animals</subject><subject>Blotting, Northern</subject><subject>Brain - embryology</subject><subject>Hippocampus - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neocortex</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Prosencephalon - embryology</subject><subject>Protein Isoforms</subject><subject>RNA, Messenger - metabolism</subject><subject>Seizure related</subject><subject>Seizures</subject><subject>Serial analysis of gene expression</subject><subject>SEZ-6</subject><subject>Signal Transduction</subject><subject>Testis - embryology</subject><subject>Thalamic eminence</subject><subject>Time Factors</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EgvLxE0CeEAwBn53YyYRQxZdUiQEYYLFc-wJGaVzsBAG_npRWMLLcLc97r-4hZB_YCTCQp3es4kWWKyWOGD9mjIsygzUyglLxTIpCrpPRL7JFtlN6ZYwBSNgkW8BFAVDyEXmcBGsa_4WO4sc8Yko-tDTUtHtBmtB_9RGziI3pBuIZW6R3F0-ZpL6lDt-xCXPfPlPTOmpc33S0DhGn0fg27ZKN2jQJ91Z7hzxcXtyPr7PJ7dXN-HyS2ZyrLkOVV6XIhyG5LKACzktbG26UZFMGZaFqVhYViko4mRtpHE5LKWQuDFPSotghh8u78xjeekydnvlksWlMi6FPWnEQglUwgMUStDGkFLHW8-hnJn5qYHrhVP841QthmnH941Qvcgergn46Q_eXWkkcgLMlgMOb7x6jTtZja9H5iLbTLvh_Kr4BT4iE7w</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Kim, Mary H.</creator><creator>Gunnersen, Jenny M.</creator><creator>Tan, Seong-Seng</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains</title><author>Kim, Mary H. ; Gunnersen, Jenny M. ; Tan, Seong-Seng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-e7498344986265191228cfa2a760b01857f0859e393d64a6adeb863643a076ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Blotting, Northern</topic><topic>Brain - embryology</topic><topic>Hippocampus - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neocortex</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Prosencephalon - embryology</topic><topic>Protein Isoforms</topic><topic>RNA, Messenger - metabolism</topic><topic>Seizure related</topic><topic>Seizures</topic><topic>Serial analysis of gene expression</topic><topic>SEZ-6</topic><topic>Signal Transduction</topic><topic>Testis - embryology</topic><topic>Thalamic eminence</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Kim, Mary H.</creatorcontrib><creatorcontrib>Gunnersen, Jenny M.</creatorcontrib><creatorcontrib>Tan, Seong-Seng</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Mary H.</au><au>Gunnersen, Jenny M.</au><au>Tan, Seong-Seng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>118</volume><issue>1</issue><spage>171</spage><epage>174</epage><pages>171-174</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><abstract>Despite its initial identification in neurons exposed to the seizure-inducing drug pentylentetrazole (PTZ), the function of the seizure-related gene
SEZ-6 remains obscure. Expression analysis indicates specific expression in the adult brain and testis, and the structure of the predicted protein suggests putative roles in cell–cell recognition and signalling. We report here that type I
SEZ-6 mRNA is strongly expressed in highly specific regions in the developing forebrain. Specifically, the pattern of
SEZ-6 expression is closely tied with the emergence of the neocortical layers and hippocampus, and implies a forebrain-specific role for this gene during development. In the adult hippocampus,
SEZ-6 appears to be a CA1-specific regional marker.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>12351182</pmid><doi>10.1016/S0925-4773(02)00238-1</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0925-4773 |
| ispartof | Mechanisms of development, 2002-10, Vol.118 (1), p.171-174 |
| issn | 0925-4773 1872-6356 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72133091 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Blotting, Northern Brain - embryology Hippocampus - metabolism Male Mice Mice, Inbred C57BL Neocortex Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Prosencephalon - embryology Protein Isoforms RNA, Messenger - metabolism Seizure related Seizures Serial analysis of gene expression SEZ-6 Signal Transduction Testis - embryology Thalamic eminence Time Factors |
| title | Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T19%3A02%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Localized%20expression%20of%20the%20seizure-related%20gene%20SEZ-6%20in%20developing%20and%20adult%20forebrains&rft.jtitle=Mechanisms%20of%20development&rft.au=Kim,%20Mary%20H.&rft.date=2002-10-01&rft.volume=118&rft.issue=1&rft.spage=171&rft.epage=174&rft.pages=171-174&rft.issn=0925-4773&rft.eissn=1872-6356&rft_id=info:doi/10.1016/S0925-4773(02)00238-1&rft_dat=%3Cproquest_cross%3E72133091%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72133091&rft_id=info:pmid/12351182&rft_els_id=S0925477302002381&rfr_iscdi=true |