Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel

Store-operated Ca++ entry (SOCE) is thought to comprise the major pathway for Ca++ entry in platelets. Recently, a number of transient receptor potential (TRP) proteins, which have been divided into 3 groups (TRPC, TRPM, and TRPV), have been suggested as SOCE channels. We report the expression and f...

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Veröffentlicht in:	Blood 2002-10, Vol.100 (8), p.2801-2811
Hauptverfasser:	Hassock, Sheila R., Zhu, Michael X., Trost, Claudia, Flockerzi, Veit, Authi, Kalwant S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Biological Transport Blood coagulation. Blood cells Blood Platelets - physiology Calcium - blood Calcium Channels - blood Calcium Channels - chemistry Calcium Channels - genetics Cells, Cultured Cyclic AMP-Dependent Protein Kinases - blood Enzyme Activation Fundamental and applied biological sciences. Psychology Fura-2 Humans Kinetics Molecular and cellular biology Molecular Sequence Data Peptide Fragments - chemistry Phosphates - blood Platelet TRPC Cation Channels TRPC6 Cation Channel
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