Pharmacokinetic basis for nonadditivity of intraocular pressure lowering in timolol combinations

The authors determined whether the ocular absorption of topically applied timolol in the pigmented rabbit was affected significantly by coadministration with either pilocarpine or epinephrine in the same drop to explain the nonadditivity in intraocular pressure lowering (IOP) seen clinically. They i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 1991-10, Vol.32 (11), p.2948-2957
Hauptverfasser:	Lee, VH, Luo, AM, Li, SY, Podder, SK, Chang, JS, Ohdo, S, Grass, GM
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Topical Animals Anterior Eye Segment - metabolism Biological and medical sciences Chromatography, High Pressure Liquid Conjunctiva - metabolism Drug Combinations Epinephrine - blood Epinephrine - pharmacokinetics Eye Eye Color Intraocular Pressure - drug effects Lens, Crystalline - metabolism Medical sciences Pharmacology. Drug treatments Pilocarpine - blood Pilocarpine - pharmacokinetics Rabbits Sclera - metabolism Timolol - blood Timolol - pharmacokinetics Tissue Distribution Uvea - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!