Magnetic resonance histology for morphologic phenotyping
Magnetic resonance histology (MRH) images of the whole mouse have been acquired at 100‐micron isotropic resolution at 2.0T with image arrays of 256 × 256 × 1024. Higher resolution (50 × 50 × 50 microns) of limited volumes has been acquired at 7.1T with image arrays of 512 × 512 × 512. Even higher re...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2002-10, Vol.16 (4), p.423-429 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Johnson, G. Allan Cofer, Gary P. Fubara, Boma Gewalt, Sally L. Hedlund, Laurence W. Maronpot, Robert R. |
| description | Magnetic resonance histology (MRH) images of the whole mouse have been acquired at 100‐micron isotropic resolution at 2.0T with image arrays of 256 × 256 × 1024. Higher resolution (50 × 50 × 50 microns) of limited volumes has been acquired at 7.1T with image arrays of 512 × 512 × 512. Even higher resolution images (20 × 20 × 20 microns) of isolated organs have been acquired at 9.4T. The volume resolution represents an increase of 625,000× over conventional clinical MRI. The technological basis is summarized that will allow basic scientists to begin using MRH as a routine method for morphologcic phenotyping of the mouse. MRH promises four unique attributes over conventional histology: 1) MRH is non‐destructive; 2) MRH exploits the unique contrast mechanisms that have made MRI so successful clinically; 3) MRH is 3‐dimensional; and 4) the data are inherently digital. We demonstrate the utility in morphologic phenotyping a whole C57BL/6J mouse. J. Magn. Reson. Imaging 2002;16:423–429. Published 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.10175 |
| format | Article |
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Allan ; Cofer, Gary P. ; Fubara, Boma ; Gewalt, Sally L. ; Hedlund, Laurence W. ; Maronpot, Robert R.</creator><creatorcontrib>Johnson, G. Allan ; Cofer, Gary P. ; Fubara, Boma ; Gewalt, Sally L. ; Hedlund, Laurence W. ; Maronpot, Robert R.</creatorcontrib><description>Magnetic resonance histology (MRH) images of the whole mouse have been acquired at 100‐micron isotropic resolution at 2.0T with image arrays of 256 × 256 × 1024. Higher resolution (50 × 50 × 50 microns) of limited volumes has been acquired at 7.1T with image arrays of 512 × 512 × 512. Even higher resolution images (20 × 20 × 20 microns) of isolated organs have been acquired at 9.4T. The volume resolution represents an increase of 625,000× over conventional clinical MRI. The technological basis is summarized that will allow basic scientists to begin using MRH as a routine method for morphologcic phenotyping of the mouse. MRH promises four unique attributes over conventional histology: 1) MRH is non‐destructive; 2) MRH exploits the unique contrast mechanisms that have made MRI so successful clinically; 3) MRH is 3‐dimensional; and 4) the data are inherently digital. We demonstrate the utility in morphologic phenotyping a whole C57BL/6J mouse. J. Magn. Reson. Imaging 2002;16:423–429. 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Allan</creatorcontrib><creatorcontrib>Cofer, Gary P.</creatorcontrib><creatorcontrib>Fubara, Boma</creatorcontrib><creatorcontrib>Gewalt, Sally L.</creatorcontrib><creatorcontrib>Hedlund, Laurence W.</creatorcontrib><creatorcontrib>Maronpot, Robert R.</creatorcontrib><title>Magnetic resonance histology for morphologic phenotyping</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Magnetic resonance histology (MRH) images of the whole mouse have been acquired at 100‐micron isotropic resolution at 2.0T with image arrays of 256 × 256 × 1024. Higher resolution (50 × 50 × 50 microns) of limited volumes has been acquired at 7.1T with image arrays of 512 × 512 × 512. Even higher resolution images (20 × 20 × 20 microns) of isolated organs have been acquired at 9.4T. The volume resolution represents an increase of 625,000× over conventional clinical MRI. The technological basis is summarized that will allow basic scientists to begin using MRH as a routine method for morphologcic phenotyping of the mouse. MRH promises four unique attributes over conventional histology: 1) MRH is non‐destructive; 2) MRH exploits the unique contrast mechanisms that have made MRI so successful clinically; 3) MRH is 3‐dimensional; and 4) the data are inherently digital. We demonstrate the utility in morphologic phenotyping a whole C57BL/6J mouse. J. Magn. Reson. Imaging 2002;16:423–429. Published 2002 Wiley‐Liss, Inc.</description><subject>active stain</subject><subject>Animals</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>magnetic resonance microscopy</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>morphology</subject><subject>mouse</subject><subject>Phenotype</subject><subject>phenotyping</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAURS0EoqWw8ANQJwakgO3kxcmIKiiFtnwIVInFchO7TUniYKeC_HtcUmBjevdJ597hIHRM8DnBmF6sCpO5RBjsoC4BSj0KUbjrMgbfIxFmHXRg7QpjHMcB7KMOoT74FFgXRROxKGWdJX0jrS5Fmcj-MrO1zvWi6Stt-oU21XLzOqZaylLXTZWVi0O0p0Ru5dH29tDL9dXz4MYb3w9Hg8uxlwQhgEewkmmIZQzAooiCkorRFAtgIY4FoWIeMMKYEiwVTLAwloFiEAJLowQU9v0eOm13K6Pf19LWvMhsIvNclFKvLWeU0JiGkQPPWjAx2lojFa9MVgjTcIL5xhPfeOLfnhx8sl1dzwuZ_qFbMQ4gLfCR5bL5Z4rfTp5GP6Ne23H-5OdvR5g3HjLfobPpkAfTh7vXGZ3yR_8LQKuB_Q</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>Johnson, G. Allan</creator><creator>Cofer, Gary P.</creator><creator>Fubara, Boma</creator><creator>Gewalt, Sally L.</creator><creator>Hedlund, Laurence W.</creator><creator>Maronpot, Robert R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200210</creationdate><title>Magnetic resonance histology for morphologic phenotyping</title><author>Johnson, G. 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Allan</creatorcontrib><creatorcontrib>Cofer, Gary P.</creatorcontrib><creatorcontrib>Fubara, Boma</creatorcontrib><creatorcontrib>Gewalt, Sally L.</creatorcontrib><creatorcontrib>Hedlund, Laurence W.</creatorcontrib><creatorcontrib>Maronpot, Robert R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, G. Allan</au><au>Cofer, Gary P.</au><au>Fubara, Boma</au><au>Gewalt, Sally L.</au><au>Hedlund, Laurence W.</au><au>Maronpot, Robert R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance histology for morphologic phenotyping</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2002-10</date><risdate>2002</risdate><volume>16</volume><issue>4</issue><spage>423</spage><epage>429</epage><pages>423-429</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Magnetic resonance histology (MRH) images of the whole mouse have been acquired at 100‐micron isotropic resolution at 2.0T with image arrays of 256 × 256 × 1024. Higher resolution (50 × 50 × 50 microns) of limited volumes has been acquired at 7.1T with image arrays of 512 × 512 × 512. Even higher resolution images (20 × 20 × 20 microns) of isolated organs have been acquired at 9.4T. The volume resolution represents an increase of 625,000× over conventional clinical MRI. The technological basis is summarized that will allow basic scientists to begin using MRH as a routine method for morphologcic phenotyping of the mouse. MRH promises four unique attributes over conventional histology: 1) MRH is non‐destructive; 2) MRH exploits the unique contrast mechanisms that have made MRI so successful clinically; 3) MRH is 3‐dimensional; and 4) the data are inherently digital. We demonstrate the utility in morphologic phenotyping a whole C57BL/6J mouse. J. Magn. Reson. Imaging 2002;16:423–429. Published 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12353257</pmid><doi>10.1002/jmri.10175</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | active stain Animals Magnetic Resonance Imaging - methods magnetic resonance microscopy Mice Mice, Inbred C57BL morphology mouse Phenotype phenotyping |
| title | Magnetic resonance histology for morphologic phenotyping |
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