Influence of fragment size on DNA quantitation using DNA-binding proteins and a sensor-based analytical system: applications in the testing of biological products

A novel immunoassay system which rapidly quantifies picogram levels of total DNA was characterized with respect to the effects of DNA length. Nine chromatographically purified HaeIII restriction fragments of ØX174 were tested. Assay performance was found to be dependent on both the amount and length...

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Veröffentlicht in:	Journal of biochemical and biophysical methods 1991-07, Vol.23 (1), p.83-93
Hauptverfasser:	King, Robert S., Panfili, Peter R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriophage phi X 174 Base Composition - drug effects Biological Products - chemistry Biological Products - standards Biopharmaceutical Cattle Chromatography Contaminant testing DNA DNA, Viral - chemistry DNA, Viral - pharmacology DNA-Binding Proteins - chemistry Immunoassay - methods Immunoassay - standards Oligonucleotides - chemistry
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