Influence of antiidiotypic antibody activity on renal transplant outcome
Influence of antiidiotypic antibody activity on renal transplant outcome. The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic a...
Gespeichert in:
| Veröffentlicht in: | Kidney international 1991-07, Vol.40 (1), p.80-85 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 85 |
|---|---|
| container_issue | 1 |
| container_start_page | 80 |
| container_title | Kidney international |
| container_volume | 40 |
| creator | Al-Muzairai, Ibrahim A. Dolhain, Radboud Taylor, Yvonne Stewart, Keith N. MacMillan, Margaret Catto, Graeme R.D. MacLeod, Alison M. |
| description | Influence of antiidiotypic antibody activity on renal transplant outcome. The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic antibodies (Ab2) to cytotoxic HLA antibodies might modulate the immune response and favorably influence renal allograft outcome. The role of antibodies (Ab3) which potentiate the cytotoxic effect of Ab1 was also studied. Pretransplant sera from 63 patients were tested for inhibitory or potentiating activity in the short antiidiotypic assay. Inhibitory activity was detected in 30 patients and in 28 the transplant survived more than a year. Of patients without antibody activity 11 of 17 had grafts surviving more than one year, and of those showing potentiating activity 11 of 16 were functioning at a year. The difference in transplant survival between the first group and the other two groups was statistically significant (P < 0.05). There was no significant difference in survival rates between the latter two groups. Potentiating activity is therefore not an independent predictor of transplant failure, whereas the presence of antiidiotypic antibody activity did correlate with improved allograft survival. |
| doi_str_mv | 10.1038/ki.1991.183 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72128787</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0085253815572736</els_id><sourcerecordid>72128787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-6bb8066abce8f42a7ffd8d0e296eba56add861a94c5827e369f2c975445b792c3</originalsourceid><addsrcrecordid>eNptkDtrHDEURoWJsddOqtSGaZLGzFrSjF6lMUm8sJDGroVGugLFs6ONpDHMv7fWuxAXqS4f93AfB6GvBK8J7uTdS1gTpciayO4MrQijXUsEY5_QCmPJWso6eYmucv6Da1YdvkAXRFFCmFqhx83kxxkmC030jZlKCC7EsuyDfU9DdEtjbAmvoSxNnJoEkxmbksyU92MlmjgXG3fwGZ17M2b4cqrX6Pnnj6eHx3b7-9fm4X7b2k6J0vJhkJhzM1iQvqdGeO-kw0AVh8EwbpyTnBjVWyapgI4rT60SrO_ZIBS13TX6fpy7T_HvDLnoXcgWxnoLxDlrQQmVQooK3h5Bm2LOCbzep7AzadEE64M3_RL0wZuu3ip9cxo7Dztw_9ijqNr_duqbbM3o6_825A-YpLznvHLsyEF18Bog6WzDQa8LCWzRLob_7n8DkjmIZQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72128787</pqid></control><display><type>article</type><title>Influence of antiidiotypic antibody activity on renal transplant outcome</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Al-Muzairai, Ibrahim A. ; Dolhain, Radboud ; Taylor, Yvonne ; Stewart, Keith N. ; MacMillan, Margaret ; Catto, Graeme R.D. ; MacLeod, Alison M.</creator><creatorcontrib>Al-Muzairai, Ibrahim A. ; Dolhain, Radboud ; Taylor, Yvonne ; Stewart, Keith N. ; MacMillan, Margaret ; Catto, Graeme R.D. ; MacLeod, Alison M.</creatorcontrib><description>Influence of antiidiotypic antibody activity on renal transplant outcome. The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic antibodies (Ab2) to cytotoxic HLA antibodies might modulate the immune response and favorably influence renal allograft outcome. The role of antibodies (Ab3) which potentiate the cytotoxic effect of Ab1 was also studied. Pretransplant sera from 63 patients were tested for inhibitory or potentiating activity in the short antiidiotypic assay. Inhibitory activity was detected in 30 patients and in 28 the transplant survived more than a year. Of patients without antibody activity 11 of 17 had grafts surviving more than one year, and of those showing potentiating activity 11 of 16 were functioning at a year. The difference in transplant survival between the first group and the other two groups was statistically significant (P < 0.05). There was no significant difference in survival rates between the latter two groups. Potentiating activity is therefore not an independent predictor of transplant failure, whereas the presence of antiidiotypic antibody activity did correlate with improved allograft survival.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.1991.183</identifier><identifier>PMID: 1921159</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antibodies, Anti-Idiotypic - analysis ; Antibodies, Anti-Idiotypic - physiology ; Biological and medical sciences ; Graft Survival - drug effects ; Graft Survival - immunology ; Humans ; Immunosuppressive Agents - therapeutic use ; Kidney Transplantation - immunology ; Medical sciences ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Time Factors</subject><ispartof>Kidney international, 1991-07, Vol.40 (1), p.80-85</ispartof><rights>1991 International Society of Nephrology</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-6bb8066abce8f42a7ffd8d0e296eba56add861a94c5827e369f2c975445b792c3</citedby><cites>FETCH-LOGICAL-c397t-6bb8066abce8f42a7ffd8d0e296eba56add861a94c5827e369f2c975445b792c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19826466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1921159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Muzairai, Ibrahim A.</creatorcontrib><creatorcontrib>Dolhain, Radboud</creatorcontrib><creatorcontrib>Taylor, Yvonne</creatorcontrib><creatorcontrib>Stewart, Keith N.</creatorcontrib><creatorcontrib>MacMillan, Margaret</creatorcontrib><creatorcontrib>Catto, Graeme R.D.</creatorcontrib><creatorcontrib>MacLeod, Alison M.</creatorcontrib><title>Influence of antiidiotypic antibody activity on renal transplant outcome</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Influence of antiidiotypic antibody activity on renal transplant outcome. The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic antibodies (Ab2) to cytotoxic HLA antibodies might modulate the immune response and favorably influence renal allograft outcome. The role of antibodies (Ab3) which potentiate the cytotoxic effect of Ab1 was also studied. Pretransplant sera from 63 patients were tested for inhibitory or potentiating activity in the short antiidiotypic assay. Inhibitory activity was detected in 30 patients and in 28 the transplant survived more than a year. Of patients without antibody activity 11 of 17 had grafts surviving more than one year, and of those showing potentiating activity 11 of 16 were functioning at a year. The difference in transplant survival between the first group and the other two groups was statistically significant (P < 0.05). There was no significant difference in survival rates between the latter two groups. Potentiating activity is therefore not an independent predictor of transplant failure, whereas the presence of antiidiotypic antibody activity did correlate with improved allograft survival.</description><subject>Antibodies, Anti-Idiotypic - analysis</subject><subject>Antibodies, Anti-Idiotypic - physiology</subject><subject>Biological and medical sciences</subject><subject>Graft Survival - drug effects</subject><subject>Graft Survival - immunology</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Kidney Transplantation - immunology</subject><subject>Medical sciences</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Time Factors</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtrHDEURoWJsddOqtSGaZLGzFrSjF6lMUm8sJDGroVGugLFs6ONpDHMv7fWuxAXqS4f93AfB6GvBK8J7uTdS1gTpciayO4MrQijXUsEY5_QCmPJWso6eYmucv6Da1YdvkAXRFFCmFqhx83kxxkmC030jZlKCC7EsuyDfU9DdEtjbAmvoSxNnJoEkxmbksyU92MlmjgXG3fwGZ17M2b4cqrX6Pnnj6eHx3b7-9fm4X7b2k6J0vJhkJhzM1iQvqdGeO-kw0AVh8EwbpyTnBjVWyapgI4rT60SrO_ZIBS13TX6fpy7T_HvDLnoXcgWxnoLxDlrQQmVQooK3h5Bm2LOCbzep7AzadEE64M3_RL0wZuu3ip9cxo7Dztw_9ijqNr_duqbbM3o6_825A-YpLznvHLsyEF18Bog6WzDQa8LCWzRLob_7n8DkjmIZQ</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>Al-Muzairai, Ibrahim A.</creator><creator>Dolhain, Radboud</creator><creator>Taylor, Yvonne</creator><creator>Stewart, Keith N.</creator><creator>MacMillan, Margaret</creator><creator>Catto, Graeme R.D.</creator><creator>MacLeod, Alison M.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910701</creationdate><title>Influence of antiidiotypic antibody activity on renal transplant outcome</title><author>Al-Muzairai, Ibrahim A. ; Dolhain, Radboud ; Taylor, Yvonne ; Stewart, Keith N. ; MacMillan, Margaret ; Catto, Graeme R.D. ; MacLeod, Alison M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-6bb8066abce8f42a7ffd8d0e296eba56add861a94c5827e369f2c975445b792c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Antibodies, Anti-Idiotypic - analysis</topic><topic>Antibodies, Anti-Idiotypic - physiology</topic><topic>Biological and medical sciences</topic><topic>Graft Survival - drug effects</topic><topic>Graft Survival - immunology</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Kidney Transplantation - immunology</topic><topic>Medical sciences</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Muzairai, Ibrahim A.</creatorcontrib><creatorcontrib>Dolhain, Radboud</creatorcontrib><creatorcontrib>Taylor, Yvonne</creatorcontrib><creatorcontrib>Stewart, Keith N.</creatorcontrib><creatorcontrib>MacMillan, Margaret</creatorcontrib><creatorcontrib>Catto, Graeme R.D.</creatorcontrib><creatorcontrib>MacLeod, Alison M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Muzairai, Ibrahim A.</au><au>Dolhain, Radboud</au><au>Taylor, Yvonne</au><au>Stewart, Keith N.</au><au>MacMillan, Margaret</au><au>Catto, Graeme R.D.</au><au>MacLeod, Alison M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of antiidiotypic antibody activity on renal transplant outcome</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>40</volume><issue>1</issue><spage>80</spage><epage>85</epage><pages>80-85</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Influence of antiidiotypic antibody activity on renal transplant outcome. The presence of cytotoxic HLA antibodies (Ab1) against donor lymphocytes in pretransplant sera is almost always associated with rapid rejection of the renal transplant. We have investigated the possibility that antiidiotypic antibodies (Ab2) to cytotoxic HLA antibodies might modulate the immune response and favorably influence renal allograft outcome. The role of antibodies (Ab3) which potentiate the cytotoxic effect of Ab1 was also studied. Pretransplant sera from 63 patients were tested for inhibitory or potentiating activity in the short antiidiotypic assay. Inhibitory activity was detected in 30 patients and in 28 the transplant survived more than a year. Of patients without antibody activity 11 of 17 had grafts surviving more than one year, and of those showing potentiating activity 11 of 16 were functioning at a year. The difference in transplant survival between the first group and the other two groups was statistically significant (P < 0.05). There was no significant difference in survival rates between the latter two groups. Potentiating activity is therefore not an independent predictor of transplant failure, whereas the presence of antiidiotypic antibody activity did correlate with improved allograft survival.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1921159</pmid><doi>10.1038/ki.1991.183</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0085-2538 |
| ispartof | Kidney international, 1991-07, Vol.40 (1), p.80-85 |
| issn | 0085-2538 1523-1755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72128787 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antibodies, Anti-Idiotypic - analysis Antibodies, Anti-Idiotypic - physiology Biological and medical sciences Graft Survival - drug effects Graft Survival - immunology Humans Immunosuppressive Agents - therapeutic use Kidney Transplantation - immunology Medical sciences Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Time Factors |
| title | Influence of antiidiotypic antibody activity on renal transplant outcome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T19%3A32%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20antiidiotypic%20antibody%20activity%20on%20renal%20transplant%20outcome&rft.jtitle=Kidney%20international&rft.au=Al-Muzairai,%20Ibrahim%20A.&rft.date=1991-07-01&rft.volume=40&rft.issue=1&rft.spage=80&rft.epage=85&rft.pages=80-85&rft.issn=0085-2538&rft.eissn=1523-1755&rft.coden=KDYIA5&rft_id=info:doi/10.1038/ki.1991.183&rft_dat=%3Cproquest_cross%3E72128787%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72128787&rft_id=info:pmid/1921159&rft_els_id=S0085253815572736&rfr_iscdi=true |