A BRCA1/2 mutation, high breast density and prominent pushing margins of a tumor independently contribute to a frequent false‐negative mammography

Female BRCA1/2 mutation carriers develop in up to 50% breast cancer (BC) before age 50 years. We investigated whether the specific histologic features of BRCA1/2‐associated breast cancer influence imaging. We correlated the mammographic results with the histology of 34 BC in BRCA1/2 mutation carrier...

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Veröffentlicht in:	International journal of cancer 2002-11, Vol.102 (1), p.91-95
Hauptverfasser:	Tilanus‐Linthorst, Madeleine, Verhoog, Leon, Obdeijn, Inge‐Marie, Bartels, Karina, Menke‐Pluymers, Marian, Eggermont, Alexander, Klijn, Jan, Meijers‐Heijboer, Hanne, van der Kwast, Theo, Brekelmans, Cecile
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Biological and medical sciences BRCA1 BRCA2 Breast - cytology breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging Carcinoma, Intraductal, Noninfiltrating - pathology Case-Control Studies Cross-Sectional Studies False Negative Reactions false‐negative Female Genes, BRCA1 Genes, BRCA2 Genital system. Mammary gland Germ-Line Mutation Heterozygote histology Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Mammography Medical sciences Middle Aged MRI Mutation Neoplasm Invasiveness - diagnostic imaging Neoplasm Invasiveness - pathology Physical Examination Radiodiagnosis. Nmr imagery. Nmr spectrometry surveillance young patients
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