Protective effects of antioxidative serotonin derivatives isolated from safflower against postischemic myocardial dysfunction

N-(p-Coumaroyl)serotonin (C) and N-feruroylserotonin (F) with antioxidative activity are present in safflower oil. The protective effects of C and F were investigated in perfused guinea-pig Langendorff hearts subjected to ischemia and reperfusion. Changes in cellular levels of high phosphorous energ...

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Veröffentlicht in:	Molecular and cellular biochemistry 2002-09, Vol.238 (1-2), p.151-162
Hauptverfasser:	Hotta, Yoshihiro, Nagatsu, Akito, Liu, Wei, Muto, Tatsuya, Narumiya, Chihiro, Lu, Xiuli, Yajima, Michio, Ishikawa, Naohisa, Miyazeki, Kunihiro, Kawai, Norio, Mizukami, Hajime, Sakakibara, Jinsaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Blood Pressure - drug effects Calcium - metabolism Carthamus tinctorius - chemistry Coronary Vessels - drug effects Coronary Vessels - physiopathology Electrodes Electron Spin Resonance Spectroscopy Female Fluorometry Free Radicals - metabolism Guinea Pigs Heart - drug effects Heart - physiopathology In Vitro Techniques Ischemia Magnetic Resonance Spectroscopy Male Microscopy, Electron Myocardial Contraction - drug effects Myocardial Ischemia - drug therapy Myocardial Ischemia - physiopathology Myocardial Reperfusion Nitric oxide Nitric Oxide - metabolism Plant Extracts - pharmacology Protective Agents - pharmacology Safflower oil Serotonin - analogs & derivatives Serotonin - pharmacology
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