Use of at-line and in-situ near-infrared spectroscopy to monitor biomass in an industrial fed-batch Escherichia coli process

One of the key goals in bioprocess monitoring is to achieve real‐time knowledge of conditions within the bioreactor, i.e., in‐situ. Near‐infrared spectroscopy (NIRS), with its ability to carry out multi‐analyte quantification rapidly with little sample presentation, is potentially applicable in this...

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