Small cell carcinoma of the cervix: A clinical and flow-cytometric study
The clinical course of 14 patients diagnosed with small cell carcinoma of the cervix (SCC) was reviewed and compared to that of 37 cases of undifferentiated large cell nonkeratonizing carcinoma (LCNK). We observed the following differences between the two: SCC patients had a higher incidence of pelv...
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| Veröffentlicht in: | Gynecologic oncology 1991-07, Vol.42 (1), p.27-33 |
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| creator | Miller, B. Dockter, M. El Torky, M. Photopulos, G. |
| description | The clinical course of 14 patients diagnosed with small cell carcinoma of the cervix (SCC) was reviewed and compared to that of 37 cases of undifferentiated large cell nonkeratonizing carcinoma (LCNK). We observed the following differences between the two: SCC patients had a higher incidence of pelvic wall involvement and distant metastasis; the development of progressive disease was more frequent in SCC than in LCNK patients; median survival time was 9 months in SCC and 40 months in LCNK patients; flow cytometry revealed aneuploidy in all SCC and in 30% of the LCNK patients; the mean DNA index was 2.24 in SCC, significantly higher than in LCNK (1.15). DNA index in cases of SCC was related to survival time. SCC of the cervix is an extremely aggressive tumor, even when compared to other undifferentiated cervical cancers. Aneuploidy is a consistent feature and thus helpful for diagnosis. Due to the wide range of values, the DNA index cannot be used for diagnostic purposes, but it is of prognostic importance in SCC cases. |
| doi_str_mv | 10.1016/0090-8258(91)90225-T |
| format | Article |
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We observed the following differences between the two: SCC patients had a higher incidence of pelvic wall involvement and distant metastasis; the development of progressive disease was more frequent in SCC than in LCNK patients; median survival time was 9 months in SCC and 40 months in LCNK patients; flow cytometry revealed aneuploidy in all SCC and in 30% of the LCNK patients; the mean DNA index was 2.24 in SCC, significantly higher than in LCNK (1.15). DNA index in cases of SCC was related to survival time. SCC of the cervix is an extremely aggressive tumor, even when compared to other undifferentiated cervical cancers. Aneuploidy is a consistent feature and thus helpful for diagnosis. Due to the wide range of values, the DNA index cannot be used for diagnostic purposes, but it is of prognostic importance in SCC cases.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/0090-8258(91)90225-T</identifier><identifier>PMID: 1655594</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aneuploidy ; Biological and medical sciences ; Carcinoma - genetics ; Carcinoma - pathology ; Carcinoma, Small Cell - genetics ; Carcinoma, Small Cell - pathology ; DNA, Neoplasm - metabolism ; Female ; Female genital diseases ; Flow Cytometry ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Prognosis ; Tumors ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Gynecologic oncology, 1991-07, Vol.42 (1), p.27-33</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-45113b4385d5e5144a500829891b6eac94f7539ab541e28d2b109d36183958113</citedby><cites>FETCH-LOGICAL-c386t-45113b4385d5e5144a500829891b6eac94f7539ab541e28d2b109d36183958113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/009082589190225T$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5140449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1655594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, B.</creatorcontrib><creatorcontrib>Dockter, M.</creatorcontrib><creatorcontrib>El Torky, M.</creatorcontrib><creatorcontrib>Photopulos, G.</creatorcontrib><title>Small cell carcinoma of the cervix: A clinical and flow-cytometric study</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>The clinical course of 14 patients diagnosed with small cell carcinoma of the cervix (SCC) was reviewed and compared to that of 37 cases of undifferentiated large cell nonkeratonizing carcinoma (LCNK). We observed the following differences between the two: SCC patients had a higher incidence of pelvic wall involvement and distant metastasis; the development of progressive disease was more frequent in SCC than in LCNK patients; median survival time was 9 months in SCC and 40 months in LCNK patients; flow cytometry revealed aneuploidy in all SCC and in 30% of the LCNK patients; the mean DNA index was 2.24 in SCC, significantly higher than in LCNK (1.15). DNA index in cases of SCC was related to survival time. SCC of the cervix is an extremely aggressive tumor, even when compared to other undifferentiated cervical cancers. Aneuploidy is a consistent feature and thus helpful for diagnosis. Due to the wide range of values, the DNA index cannot be used for diagnostic purposes, but it is of prognostic importance in SCC cases.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma, Small Cell - genetics</subject><subject>Carcinoma, Small Cell - pathology</subject><subject>DNA, Neoplasm - metabolism</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Flow Cytometry</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLwzAUx4Moc06_gUIPInqoJmnSJR6EMdQJAw_Oc0iTFCNto0k73bc3tWPevORB3u__eO8HwCmC1wii_AZCDlOGKbvk6IpDjGm62gNjBDlNc0b5PhjvkENwFMI7hDCDCI_ACOWUUk7GYPFSy6pKlOkf6ZVtXC0TVybtm4m_fm2_b5NZoirbWCWrRDY6KSv3lapN62rTequS0HZ6cwwOSlkFc7KtE_D6cL-aL9Ll8-PTfLZMVcbyNiUUoawgGaOaGooIkRRChjnjqMiNVJyUU5pxWVCCDGYaF_EeneWIZZyymJ2Ai2Huh3efnQmtqG3o15eNcV0QU4ww6fEJIAOovAvBm1J8eFtLvxEIil6g6O2I3o7gSPwKFKsYO9vO74ra6L_QYCz2z7d9GaKQ0stG2bDD4kmQEB6xuwEz0cXaGi-CsqZRRltvVCu0s__v8QOQMonB</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>Miller, B.</creator><creator>Dockter, M.</creator><creator>El Torky, M.</creator><creator>Photopulos, G.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910701</creationdate><title>Small cell carcinoma of the cervix: A clinical and flow-cytometric study</title><author>Miller, B. ; Dockter, M. ; El Torky, M. ; Photopulos, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-45113b4385d5e5144a500829891b6eac94f7539ab541e28d2b109d36183958113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma, Small Cell - genetics</topic><topic>Carcinoma, Small Cell - pathology</topic><topic>DNA, Neoplasm - metabolism</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Flow Cytometry</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, B.</creatorcontrib><creatorcontrib>Dockter, M.</creatorcontrib><creatorcontrib>El Torky, M.</creatorcontrib><creatorcontrib>Photopulos, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, B.</au><au>Dockter, M.</au><au>El Torky, M.</au><au>Photopulos, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small cell carcinoma of the cervix: A clinical and flow-cytometric study</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>42</volume><issue>1</issue><spage>27</spage><epage>33</epage><pages>27-33</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>The clinical course of 14 patients diagnosed with small cell carcinoma of the cervix (SCC) was reviewed and compared to that of 37 cases of undifferentiated large cell nonkeratonizing carcinoma (LCNK). We observed the following differences between the two: SCC patients had a higher incidence of pelvic wall involvement and distant metastasis; the development of progressive disease was more frequent in SCC than in LCNK patients; median survival time was 9 months in SCC and 40 months in LCNK patients; flow cytometry revealed aneuploidy in all SCC and in 30% of the LCNK patients; the mean DNA index was 2.24 in SCC, significantly higher than in LCNK (1.15). DNA index in cases of SCC was related to survival time. SCC of the cervix is an extremely aggressive tumor, even when compared to other undifferentiated cervical cancers. Aneuploidy is a consistent feature and thus helpful for diagnosis. Due to the wide range of values, the DNA index cannot be used for diagnostic purposes, but it is of prognostic importance in SCC cases.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1655594</pmid><doi>10.1016/0090-8258(91)90225-T</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| subjects | Adult Aged Aged, 80 and over Aneuploidy Biological and medical sciences Carcinoma - genetics Carcinoma - pathology Carcinoma, Small Cell - genetics Carcinoma, Small Cell - pathology DNA, Neoplasm - metabolism Female Female genital diseases Flow Cytometry Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Prognosis Tumors Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology |
| title | Small cell carcinoma of the cervix: A clinical and flow-cytometric study |
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